Results 61 to 70 of about 290,382 (301)

MOESM2 of A novel resveratrol derivative induces mitotic arrest, centrosome fragmentation and cancer cell death by inhibiting γ-tubulin [PDF]

, 2019
Additional file 2: Figure S2. Alterations of mitotic spindle structure, cell cycle progression and apoptosis in SW620 cells. (A) SW620 cells were treated with 80 µM 3,4,4′-TMS for 2 h, fixed and stained with anti-α-tubulin and anti-γ-tubulin antibodies ...
Zulema Percario (6574118), Francesca Degrassi (231524), Daniela Trisciuoglio (132747), Renata Cozzi (651264), Gianandrea Traversi (6574112), David Staid (6574115), Veronica Morea (1495819), Mario Fiore (231517), Roberto Antonioletti (201575)   +8 more
core   +1 more source

Novel Suicide Ligands of Tubulin Arrest Cancer Cells in S-Phase

Neoplasia: An International Journal for Oncology Research, 1999
It is presently accepted that the mechanism of action for all anti-tumor tubulin ligands involves the perturbation of microtubule dynamics during the G2/M phase of cell division and subsequent entry into apoptosis 1].
Ashley Davis, Jian-Dong Jiang, Kim M. Middleton, Yue Wang, Imre Weisz, Yi-He Ling, J. George Bekesi   +6 more
doaj   +1 more source

Methoxy and bromo scans on N-(5-methoxyphenyl) methoxybenzenesulphonamides reveal potent cytotoxic compounds, especially against the human breast adenocarcinoma MCF7 cell line

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Thirty seven N-(5-methoxyphenyl)-4-methoxybenzenesulphonamide with methoxy or/and bromo substitutions (series 1-4) and with different substituents on the sulphonamide nitrogen have been synthesised.
Myriam González, María Ovejero-Sánchez, Alba Vicente-Blázquez, Manuel Medarde, Rogelio González-Sarmiento, Rafael Peláez   +5 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Exploitation of the protein tubulin for controlling African trypanosomiasis [PDF]

, 2005
This thesis presents the results of an investigation into the structural protein, tubulin, as a potential target for anti-trypanosomatid drug discovery and vaccine development.
Giles, Natalie
core   +1 more source

Template-free 13-protofilament microtubule–MAP assembly visualized at 8 A resolution [PDF]

, 2010
Microtubule-associated proteins (MAPs) are essential for regulating and organizing cellular microtubules (MTs). However, our mechanistic understanding of MAP function is limited by a lack of detailed structural information. Using cryo-electron microscopy
Houdusse, A., Amigues, Beatrice, Clare, Daniel K., Thomas, Geraint, Perderiset, Mylene, Franck J. Fourniol, Fiona Francis, Moores, Carolyn A., Carolyn A. Moores, Daniel K. Clare, Thomas, G., Sindelar, C.V., Fourniol, Franck, Amigues, B., Houdusse, Anne, Franck Fourniol, Charles V. Sindelar, Fourniol, Franck J., Anne Houdusse, Geraint Thomas, Francis, F., Sindelar, Charles V., Francis, Fiona, Perderiset, M., Beatrice Amigues, Mylene Perderiset   +25 more
core   +1 more source

Design, synthesis, in silico studies, and apoptotic antiproliferative activity of novel thiazole-2-acetamide derivatives as tubulin polymerization inhibitors

Frontiers in Chemistry
IntroductionTubulin polymerization inhibitors have emerged as interesting anticancer therapies. We present the design, synthesis, and structural elucidation of novel thiazole-based derivatives to identify novel tubulin inhibitors with potent ...
Lamya H. Al-Wahaibi, Ali M. Elshamsy, Taha F. S. Ali, Bahaa G. M. Youssif, Stefan Bräse, Mohamed Abdel-Aziz, Nawal A. El-Koussi, Nawal A. El-Koussi   +7 more
doaj   +1 more source

Proteolysis of tubulin and the substructure of the tubulin dimer.

Journal of Biological Chemistry, 1986
The alpha and beta subunits of tubulin each have a single highly reactive site for a variety of proteases that divides each subunit into two unequal regions. The position of cleavage is not the same for alpha and beta, since alpha is consistently cleaved into about 38- and 14-kDa pieces, while beta is cleaved into about 34- and 21-kDa pieces.
D L, Sackett, J, Wolff
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Tubulin-G protein interaction: The dynamic role of tubulin in the regulation of the neuronal adenylyl cyclase. [PDF]

, 1990
Tubulin-G protein interaction: The dynamic role of tubulin in the regulation of the neuronal adenylyl ...
Nan. Wang (7984148)
core