Results 51 to 60 of about 478,815 (317)

Local hepatic immune response in rats during primary infection with Fasciola hepatica

Parasite, 2000
The distribution of lymphocyte subpopulations (TCD4+ , TCD8+, TCD43+ and Ig+ cells), macrophages and eosinophils were analysed in the inflammatory infiltrates associated with hepatic lesions and in hepatic lymph nodes (HLN) from rats experimentally ...
Tliba O., Sibille P., Boulard C., Chauvin A.   +3 more
doaj   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Antibodies in falciparum malaria: what matters most, quantity or quality?

Memorias do Instituto Oswaldo Cruz, 1992
In view of the recent demonstration that antibodies that are protective agains Plasmodium falciparum malaria may act in collaboration with blood monocytes, we have investigated the isotype content of sera from individuals with defined clinical states of ...
Hasnaa Bouharoun-Tayoun, Pierre Druilhe
doaj   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

The potential to improve Lyme disease diagnostics through quantification of immunoglobulin class switching patterns

Journal of Clinical Microbiology
N. Nair, A. Marques , E. J. Horn, G. Brown et al., J Clin Microbiol 63:e0034725, 2025, https://doi.org/10.1128/jcm.00347-25 present data to demonstrate that infection by Borrelia burgdorferi, the primary causative agent of Lyme disease in the USA, leads ...
Anna M. Schotthoefer
doaj   +1 more source

Immunoglobulin class‐switch recombination: Mechanism, regulation, and related diseases

MedComm
Maturation of the secondary antibody repertoire requires class‐switch recombination (CSR), which switches IgM to other immunoglobulins (Igs), and somatic hypermutation, which promotes the production of high‐affinity antibodies.
Jiachen Liu, Ke Zhang, Xu Zhang, Fei Guan, H. Zeng, Masato Kubo, Pamela Lee, Fabio Candotti, Louisa K. James, Niels Olsen Saraiva Câmara, K. Benlagha, Jia-Hui Lei, H. Forsman, Lu Yang, Wei Xiao, Zheng Liu, Chao-Hong Liu   +16 more
semanticscholar   +1 more source

Antigen-specific influence of GM/KM allotypes on IgG isotypes and association of GM allotypes with susceptibility to Plasmodium falciparum malaria [PDF]

, 2009
Background Plasmodium falciparum malaria is a complex disease in which genetic and environmental factors influence susceptibility. IgG isotypes are in part genetically controlled, and GM/KM allotypes are believed to be involved in this control.
Thor G Theander, Troye-Blomberg, Marita,, Marita Troye-Blomberg, ElGhazali, Gehad, ElGhazali Gehad, Janardan P Pandey, Giha, Hayder A., Pandey, Janardan P, Giha Hayder A, Iriemenam, Nnaemeka C., Nasr, Amre, Gehad ElGhazali, David Arnot, Giha, Hayder A, Nasr, Amre,, Troye-Blomberg, Marita, Theander, Thor G., Pandey, Janardan P., Berzins, Klavs, Berzins Klavs, Berzins, Klavs,, Hayder A Giha, Nnaemeka C Iriemenam, Theander, Thor G, Theander Thor G, Iriemenam, Nnaemeka C, Troye-Blomberg Marita, Nasr Amre, Klavs Berzins, Iriemenam Nnaemeka C, Arnot, David, Amre Nasr, Arnot David, Pandey Janardan P, Iriemenam, Nnaemeka C.,   +34 more
core   +1 more source

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

Immunoproteomics reveal increased serum IgG3/5 binding to Dermatophagoides and yeast protein antigens in severe equine asthma in a preliminary study

Frontiers in Immunology, 2023
IntroductionSevere equine asthma (SEA) is a common, chronic respiratory disease of horses characterized by hyperreactivity to hay dust which has many similarities to severe neutrophilic asthma in humans.
Christiane L. Schnabel, Maria-Christin Jentsch, Sabrina Lübke, Sarah Kaiser-Thom, Vinzenz Gerber, Susanne Vrtala, Huey-Jy Huang, Claudio Rhyner, Claudio Rhyner, Bettina Wagner, Ralf Hoffmann, Daniela  Volke   +11 more
doaj   +1 more source