Results 51 to 60 of about 20,447 (254)

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Tumor cells of hairy cell leukemia express multiple clonally related immunoglobulin isotypes via RNA splicing

, 2001
Hairy cell leukemia (HCL) derives from a mature B cell and expresses markers associated with activation. Analysis of immunoglobulin variable region genes has revealed somatic mutation in most cases, consistent with an origin from a cell that has ...
Mockridge, Christopher I., Stevenson, Freda K., Surinder S. Sahota, Francesco Forconi, Donatella Raspadori, Freda K. Stevenson, Christopher I. Mockridge, Forconi, Francesco, Raspadori, Donatella, Francesco Lauria, Sahota, Surinder S., Lauria, Francesco   +11 more
core   +1 more source

Antibodies in falciparum malaria: what matters most, quantity or quality?

Memorias do Instituto Oswaldo Cruz, 1992
In view of the recent demonstration that antibodies that are protective agains Plasmodium falciparum malaria may act in collaboration with blood monocytes, we have investigated the isotype content of sera from individuals with defined clinical states of ...
Hasnaa Bouharoun-Tayoun, Pierre Druilhe
doaj   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

Supplementary Table S1: Properties of Antibody Isotypes from Targeting PD-1 or PD-L1 in Metastatic Kidney Cancer: Combination Therapy in the First-Line Setting

, 2020
Immunoglobulin Isotypes and Relative Biologic ...
David H. Aggen (15027077), Brian I. Rini (9081440), Charles G. Drake (7549529)   +2 more
core   +1 more source

Immunoproteomics reveal increased serum IgG3/5 binding to Dermatophagoides and yeast protein antigens in severe equine asthma in a preliminary study

Frontiers in Immunology, 2023
IntroductionSevere equine asthma (SEA) is a common, chronic respiratory disease of horses characterized by hyperreactivity to hay dust which has many similarities to severe neutrophilic asthma in humans.
Christiane L. Schnabel, Maria-Christin Jentsch, Sabrina Lübke, Sarah Kaiser-Thom, Vinzenz Gerber, Susanne Vrtala, Huey-Jy Huang, Claudio Rhyner, Claudio Rhyner, Bettina Wagner, Ralf Hoffmann, Daniela  Volke   +11 more
doaj   +1 more source

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

Variant B cell receptor isotype functions differ in hairy cell leukemia with mutated BRAF and IGHV genes. [PDF]

PLoS ONE, 2014
A functional B-cell receptor (BCR) is critical for survival of normal B-cells, but whether it plays a comparable role in B-cell malignancy is as yet not fully delineated.
Nicola J Weston-Bell, Francesco Forconi, Hanneke C Kluin-Nelemans, Surinder S Sahota   +3 more
doaj   +1 more source

Decoding Spatial Heterogeneity and Multi‐Omics Regulation with Hierarchical Graph Learning

Advanced Science, EarlyView.
ABSTRACT Recent advances in spatial multi‐omics technologies have enabled the simultaneous profiling of multiple molecular layers within the same tissue slice, providing unprecedented opportunities to investigate tissue spatial organization. However, most existing computational methods identify spatial domains in a purely data‐driven manner, rarely ...
Jiazhou Chen, Jiahui Xie, Yi Liao, Junyu Li, Longqi Liu, Xin Gao, Hongmin Cai   +6 more
wiley   +1 more source

MOESM1 of Intratumoral immunoglobulin isotypes predict survival in lung adenocarcinoma subtypes

, 2019
Additional file 1: Figure S1. Non-silent mutation burden correlates with IGHG1/IGH proportion in LUAD subgroups. Figure S2. IgG1 clonality. Figure S3. Exploring IGH motifs linked to IgG1-mediated survival in KRASmut LUAD. Figure S4.
G. Sharonov (7587482), M. Turchaninova (7587488), M. Shugay (7587494), A. Zaretsky (7587491), E. Serebrovskaya (7587485), D. Chudakov (7587497), O. Isaeva (7587479)   +6 more
core   +1 more source