Results 21 to 30 of about 478,815 (317)

Dynamics of immunoglobulin G subclasses during the first two years of life in Malawian infants born to HIV-positive mothers

BMC Pediatrics, 2020
Background Maternal antibodies are key components of the protective responses of infants who are unable to produce their own IgG until 6 months of life. There is evidence that HIV-exposed uninfected children (HEU) have IgG levels abnormalities, that can ...
Silvia Baroncelli, Clementina Maria Galluzzo, Giuseppe Liotta, Mauro Andreotti, Stefano Orlando, Fausto Ciccacci, Haswell Jere, Richard Luhanga, Jean Baptiste Sagno, Roberta Amici, Maria Cristina Marazzi, Marina Giuliano   +11 more
doaj   +1 more source

Immunoglobulin isotype influences affinity and specificity [PDF]

Proceedings of the National Academy of Sciences, 2012
For almost half a century the Ig molecule has been considered a bifunctional molecule consisting of two independent regions, a variable (V) region responsible for specificity and affinity, and a constant (C) region responsible for such effector functions as complement activation and interaction with Fc receptors.
Arturo, Casadevall, Alena, Janda
openaire   +2 more sources

Onset of immune senescence defined by unbiased pyrosequencing of human immunoglobulin mRNA repertoires. [PDF]

PLoS ONE, 2012
The immune system protects us from foreign substances or pathogens by generating specific antibodies. The variety of immunoglobulin (Ig) paratopes for antigen recognition is a result of the V(D)J rearrangement mechanism, while a fast and efficient immune
Florian Rubelt, Volker Sievert, Florian Knaust, Christian Diener, Theam Soon Lim, Karl Skriner, Edda Klipp, Richard Reinhardt, Hans Lehrach, Zoltán Konthur   +9 more
doaj   +1 more source

The immunopathology of human schistosomiasis-III: immunoglobulin isotype profiles and response to praziquantel

Memorias do Instituto Oswaldo Cruz, 1996
Immunoglobulin (Ig) isotype (IgG, IgG1, IgG2, IgG3, IgG4, IgM, IgD and IgE) levels were investigated, both pre- and post-treatment with praziquantel (PZQ), in 43 adults and children chronically infected with Schistosoma mansoni , by means of a two-site ...
Romelia M Ramírez, Evelia Ceballos, Belkisyolé Alarcón de Noya, Oscar Noya, Nicolás Bianco   +4 more
doaj   +1 more source

Immunoglobulin genes and diversity: what we have learned from domestic animals

Journal of Animal Science and Biotechnology, 2012
This review focuses on the diversity of immunoglobulin (Ig) genes and Ig isotypes that are expressed in domestic animals. Four livestock species—cattle, sheep, pigs, and horses—express a full range of Ig heavy chains (IgHs), including μ, δ, γ, ϵ, and α ...
Sun Yi, Liu Zhancai, Ren Liming, Wei Zhiguo, Wang Ping, Li Ning, Zhao Yaofeng   +6 more
doaj   +1 more source

Pregnancy mediated improvement of rheumatoid arthritis

Swiss Medical Weekly, 2012
QUESTION UNDER STUDY: To investigate pregnancy related changes of rheumatoid factor (RF) isotypes and anti-citrullinated protein antibodies (ACPA) and their association with disease activity and therapy in patients with rheumatoid arthritis.
Frauke Förger, Inka Vallbracht, Klaus Helmke, Peter Matthias Villiger, Monika Ostensen   +4 more
doaj   +1 more source

Exceptionally long CDR3H are not isotype restricted in bovine immunoglobulins. [PDF]

PLoS ONE, 2013
Exceptionally long third complementarity determining regions of the heavy chain (CDR3H) were previously described as a specificity of bovine IgG and IgM immunoglobulins.
Stefanie Walther, Claus-Peter Czerny, Ulrike S Diesterbeck   +2 more
doaj   +1 more source

Comparable Long-Term Rabies Immunity in Foxes after IntraMuscular and Oral Application Using a Third-Generation Oral Rabies Virus Vaccine

Vaccines, 2021
The live genetically-engineered oral rabies virus (RABV) variant SPBN GASGAS induces long-lasting immunity in foxes and protection against challenge with an otherwise lethal dose of RABV field strains both after experimental oral and parenteral routes of
Verena te Kamp, Virginia Friedrichs, Conrad M. Freuling, Ad Vos, Madlin Potratz, Antonia Klein, Luca M. Zaeck, Elisa Eggerbauer, Peter Schuster, Christian Kaiser, Steffen Ortmann, Antje Kretzschmar, Katharina Bobe, Michael R. Knittler, Anca Dorhoi, Stefan Finke, Thomas Müller   +16 more
doaj   +1 more source

Heatmap representing the differences in total immunoglobulin and immunoglobulin heavy chain relative abundance between neonates, foals, and adult horses.

, 2023
Yellow tones indicate a significant lower relative abundance. Groups are shown in columns, the rows represent the immunoglobulin isotypes.
Adina R. Bujold (16940729), David W. Horohov (11101363), Phillip A. Wilmarth (231403), Alejandra A. Rivolta (12088904), Brett S. Phinney (112933), Macarena G. Sanz (16940735), Joseph P. Navelski (16940732)   +6 more
core   +1 more source

Integrative transcriptome and chromatin landscape analysis reveals distinct epigenetic regulations in human memory B cells

Nature Communications, 2020
Human memory B cells differentiate from naïve B cells and can express different immunoglobulin (Ig) isotypes resulted from class-switch recombination.
Justin B. Moroney, Anusha Vasudev, Alexander Pertsemlidis, Hong Zan, Paolo Casali   +4 more
doaj   +1 more source