Results 11 to 20 of about 478,815 (317)

Trajectories of class–switching-related egg and cow's milk allergen-specific immunoglobulin isotype formation and its modification by eczema with low- and high-affinity immunoglobulin E during early infancy

Immunity, Inflammation and Disease, 2019
Introduction Allergen‐specific immunoglobulin isotype formation associated with immunoglobulin class‐switching during the lactation period is the immunological background for food allergy in infants.
Makoto Irahara, Yukihiro Ohya, Hiroshi Kido   +2 more
exaly   +2 more sources

Aging and immunoglobulin isotype patterns in oral tolerance [PDF]

Brazilian Journal of Medical and Biological Research, 1998
In the present review we address oral tolerance as an important biological phenomenon and discuss how it is affected by aging. Other factors such as frequency of feeding and previous digestion of the antigen also seem to influence the establishment of ...
A.M.C. Faria, S.M. Ficker, E. Speziali, J.S. Menezes, B. Stransky, B.A. Verdolin, W.M. Lahmann, V.S. Rodrigues, N.M. Vaz   +8 more
doaj   +5 more sources

Human Antibody Isotypes, Subclasses, Allotypes and Fc Biology: Clinical Implications in Infectious Diseases, Autoimmunity, and Cancer. [PDF]

Pharmaceuticals (Basel)
Therapeutic antibodies have transformed the management of infectious diseases, autoimmune disorders, and cancer, yet most approved agents continue to rely on a limited range of IgG-based Fc scaffolds.
Gautam S, Singh S, Thakkar V, Joshi D, Kumar S.   +4 more
europepmc   +2 more sources

Tissue Transglutaminase Immunoglobulin Isotypes in Children With Untreated and Treated Celiac Disease

Journal of Pediatric Gastroenterology and Nutrition - JPGN, 2003
ObjectivesTissue transglutaminase (tTG) autoantibodies are serologic markers for celiac disease (CD). The aim was to determine the diagnostic sensitivity and specificity of different immunoglobulin isotypes against tTG. MethodsImmunoglobulin A (IgA)-tTG,
D. Agardh, S. Borulf, Å. Lernmark, S. Ivarsson   +3 more
semanticscholar   +2 more sources

Revisiting the impact of immunoglobulin isotypes in multiple myeloma

Blood, 2020
Background Multiple Myeloma (MM) is a malignancy of terminally differentiated B lymphocytes (plasma cells, PCs) characterized by secretion of immunoglobulins and/or light chains (LCs). Association of immunoglobulin isotypes with survival in the context of contemporary therapies and accounting for modern prognostic factors has not been ...
S. Bal, S. Giri, K. Godby, L. Costa
semanticscholar   +3 more sources

SURFACE IMMUNOGLOBULIN ALLOTYPES AND ISOTYPES ON RABBIT LYMPHOCYTES.

, 1978
SURFACE IMMUNOGLOBULIN ALLOTYPES AND ISOTYPES ON RABBIT ...
BEVERLEY ANN. BESSINGER (7988327)
core   +6 more sources

Differences in the immunoglobulin gene repertoires of IgG versus IgA multiple myeloma allude to distinct immunopathogenetic trajectories

Frontiers in Oncology, 2023
The analysis of the immunogenetic background of multiple myeloma (MM) has proven key to understanding disease ontogeny. However, limited information is available regarding the immunoglobulin (IG) gene repertoire in MM cases carrying different heavy chain
Glykeria Gkoliou, Glykeria Gkoliou, Andreas Agathangelidis, Georgos Karakatsoulis, Georgos Karakatsoulis, Chrysavgi Lalayanni, Apostolia Papalexandri, Alejandro Medina, Elisa Genuardi, Katerina Chlichlia, Evdoxia Hatjiharissi, Maria Papaioannou, Evangelos Terpos, Cristina Jimenez, Ioanna Sakellari, Simone Ferrero, Marco Ladetto, Ramon Garcia Sanz, Chrysoula Belessi, Kostas Stamatopoulos, Kostas Stamatopoulos   +20 more
doaj   +1 more source

Origin of Immunoglobulin Isotype Switching [PDF]

Current Biology, 2012
From humans to frogs, immunoglobulin class switching introduces different effector functions to antibodies through an intrachromosomal DNA recombination process at the heavy-chain locus. Although there are two conventional antibody classes (IgM, IgW) in sharks, their heavy chains are encoded by 20 to >100 miniloci. These representatives of the earliest
Zhu, Catherine, Lee, Victor, Finn, Alyssa, Senger, Kate, Zarrin, Ali A., Du Pasquier, Louis, Hsu, Ellen   +6 more
openaire   +4 more sources

Ku80 is required for immunoglobulin isotype switching [PDF]

The EMBO Journal, 1998
Isotype switching is the DNA recombination mechanism by which antibody genes diversify immunoglobulin effector functions. In contrast to V(D)J recombination, which is mediated by RAG1, RAG2 and DNA double-stranded break (DSB) repair proteins, little is known about the mechanism of switching.
R, Casellas, A, Nussenzweig, R, Wuerffel, R, Pelanda, A, Reichlin, H, Suh, X F, Qin, E, Besmer, A, Kenter, K, Rajewsky, M C, Nussenzweig   +10 more
openaire   +2 more sources

T2T-CHM13 versus hg38: accurate identification of immunoglobulin isotypes from scRNA-seq requires a genome reference matched for ancestry. [PDF]

NAR Genom Bioinform
Antibody production by B cells is essential for protective immunity. The clonal selection theory posits that each mature B cell has a unique immunoglobulin receptor generated through random gene recombination and, when stimulated to differentiate into an
Nie J, Tellier J, Tarasova I, Nutt SL, Smyth GK.   +4 more
europepmc   +2 more sources