Results 11 to 20 of about 20,447 (254)

Onset of immune senescence defined by unbiased pyrosequencing of human immunoglobulin mRNA repertoires. [PDF]

PLoS ONE, 2012
The immune system protects us from foreign substances or pathogens by generating specific antibodies. The variety of immunoglobulin (Ig) paratopes for antigen recognition is a result of the V(D)J rearrangement mechanism, while a fast and efficient immune
Florian Rubelt, Volker Sievert, Florian Knaust, Christian Diener, Theam Soon Lim, Karl Skriner, Edda Klipp, Richard Reinhardt, Hans Lehrach, Zoltán Konthur   +9 more
doaj   +3 more sources

Three IgH isotypes, IgM, IgA and IgY are expressed in Gentoo penguin and zebra finch. [PDF]

PLoS ONE, 2017
Previous studies on a limited number of birds suggested that the IgD-encoding gene was absent in birds. However, one of our recent studies showed that the gene was definitely expressed in the ostrich and emu.
Binyue Han, Yan Li, Haitang Han, Yaofeng Zhao, Qingjie Pan, Liming Ren   +5 more
doaj   +2 more sources

Fc-Galactosylation of Human Immunoglobulin Gamma Isotypes Improves C1q Binding and Enhances Complement-Dependent Cytotoxicity [PDF]

Frontiers in Immunology, 2017
Binding of the complement component C1q to the CH2 domain of antigen-bound immunoglobulin gamma (IgG) activates the classical complement pathway and depends on its close proximity to Fc fragments of neighboring antibodies. IgG subclasses contain a highly
Benjamin Peschke, Christian W. Keller, Patrick Weber, Isaak Quast, Isaak Quast, Jan D. Lünemann, Jan D. Lünemann   +6 more
doaj   +4 more sources

Influence of ultra-endurance exercise on immunoglobulin isotypes and subclasses [PDF]

British Journal of Sports Medicine, 2005
Background: Strenuous exercise is associated with tissue damage. This activates the innate immune system and local inflammation. Interaction between innate and adaptive immunity is essential for maintaining health, suggesting that the adaptive immune system may also be altered by exercise. Objectives:
A J, McKune, L L, Smith, S J, Semple, A A, Wadee   +3 more
openaire   +3 more sources

T2T-CHM13 versus hg38: accurate identification of immunoglobulin isotypes from scRNA-seq requires a genome reference matched for ancestry. [PDF]

NAR Genom Bioinform
Antibody production by B cells is essential for protective immunity. The clonal selection theory posits that each mature B cell has a unique immunoglobulin receptor generated through random gene recombination and, when stimulated to differentiate into an
Nie J, Tellier J, Tarasova I, Nutt SL, Smyth GK.   +4 more
europepmc   +2 more sources

Origin of Immunoglobulin Isotype Switching [PDF]

Current Biology, 2012
From humans to frogs, immunoglobulin class switching introduces different effector functions to antibodies through an intrachromosomal DNA recombination process at the heavy-chain locus. Although there are two conventional antibody classes (IgM, IgW) in sharks, their heavy chains are encoded by 20 to >100 miniloci. These representatives of the earliest
Zhu, Catherine, Lee, Victor, Finn, Alyssa, Senger, Kate, Zarrin, Ali A., Du Pasquier, Louis, Hsu, Ellen   +6 more
openaire   +4 more sources

Ku80 is required for immunoglobulin isotype switching [PDF]

The EMBO Journal, 1998
Isotype switching is the DNA recombination mechanism by which antibody genes diversify immunoglobulin effector functions. In contrast to V(D)J recombination, which is mediated by RAG1, RAG2 and DNA double-stranded break (DSB) repair proteins, little is known about the mechanism of switching.
R, Casellas, A, Nussenzweig, R, Wuerffel, R, Pelanda, A, Reichlin, H, Suh, X F, Qin, E, Besmer, A, Kenter, K, Rajewsky, M C, Nussenzweig   +10 more
openaire   +2 more sources

How Estrogen, Testosterone, and Sex Differences Influence Serum Immunoglobulin Isotype Patterns in Mice and Humans

Viruses, 2023
Females often exhibit superior immune responses compared to males toward vaccines and pathogens such as influenza viruses and SARS-CoV-2. To help explain these differences, we first studied serum immunoglobulin isotype patterns in C57BL/6 male and female
Sherri L. Surman, Bart G. Jones, Rhiannon R. Penkert, Robert E. Sealy, Tony Marion, Paul G. Thomas, Geoffrey Neale, Beisi Xu, Julia L. Hurwitz   +8 more
doaj   +1 more source

Dynamics of immunoglobulin G subclasses during the first two years of life in Malawian infants born to HIV-positive mothers

BMC Pediatrics, 2020
Background Maternal antibodies are key components of the protective responses of infants who are unable to produce their own IgG until 6 months of life. There is evidence that HIV-exposed uninfected children (HEU) have IgG levels abnormalities, that can ...
Silvia Baroncelli, Clementina Maria Galluzzo, Giuseppe Liotta, Mauro Andreotti, Stefano Orlando, Fausto Ciccacci, Haswell Jere, Richard Luhanga, Jean Baptiste Sagno, Roberta Amici, Maria Cristina Marazzi, Marina Giuliano   +11 more
doaj   +1 more source

Immunoglobulin isotype influences affinity and specificity [PDF]

Proceedings of the National Academy of Sciences, 2012
For almost half a century the Ig molecule has been considered a bifunctional molecule consisting of two independent regions, a variable (V) region responsible for specificity and affinity, and a constant (C) region responsible for such effector functions as complement activation and interaction with Fc receptors.
Arturo, Casadevall, Alena, Janda
openaire   +2 more sources