Results 161 to 170 of about 5,265 (218)
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Journal of Medicinal Chemistry, 1977
A series of 3-halo-5-phenyl- and 3-phenyl-5-haloisoxazoles has demonstrated anthelmintic activity at doses ranging from 16 to 500 mg/kg orally against the rat roundworm, Nippostrongylus braziliensis. In the 5-phenyl series a halogen at the 3 position of the isoxazole ring was required for activity.
J B, Carr, H G, Durham, D K, Hass
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A series of 3-halo-5-phenyl- and 3-phenyl-5-haloisoxazoles has demonstrated anthelmintic activity at doses ranging from 16 to 500 mg/kg orally against the rat roundworm, Nippostrongylus braziliensis. In the 5-phenyl series a halogen at the 3 position of the isoxazole ring was required for activity.
J B, Carr, H G, Durham, D K, Hass
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Canadian Journal of Chemistry, 1974
X-Ray, n.m.r., and dielectric studies show that the hydrate of isoxazole is a typical type II clathrate hydrate in structure, in reorientation rates of host and guest molecules, and in composition.
Gough, S.R. +3 more
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X-Ray, n.m.r., and dielectric studies show that the hydrate of isoxazole is a typical type II clathrate hydrate in structure, in reorientation rates of host and guest molecules, and in composition.
Gough, S.R. +3 more
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Isoxazoles with antipicornavirus activity
Journal of Medicinal Chemistry, 1985The synthesis and evaluation of a series of 3,5-disubstituted isoxazoles as antipicornavirus agents have led to the discovery of several compounds effective in vitro against rhinovirus type 2 and poliovirus type 2. Compound 32 was found more effective than 4',6-dichloroflavan against both viruses and was evaluated orally in mice infected ...
G D, Diana +5 more
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2001
Publisher Summary Natural products based on the isoxazole (1,2-oxazole) skeleton constitute a small, heterogeneous group of natural products encompassing at present more than 90 structures. This group has not traditionally been classified as a special alkaloid group and has never been reviewed as a group previously.
L, Rahbaek, C, Christophersen
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Publisher Summary Natural products based on the isoxazole (1,2-oxazole) skeleton constitute a small, heterogeneous group of natural products encompassing at present more than 90 structures. This group has not traditionally been classified as a special alkaloid group and has never been reviewed as a group previously.
L, Rahbaek, C, Christophersen
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Isoxazoles I: Protonation of Isoxazole Derivatives in Aqueous Sulfuric Acid
Journal of Pharmaceutical Sciences, 1973The protonation of 3-amino-5-methylisoxazole, 5-amino-3,4-dimethylisoxazole, sulfamethoxazole (N-sulfanilamido-5-methyl-3-isoxazole), and sulfisoxazole (N-sulfanilamido-3,4-dimethyl-5-isoxazole) in aqueous sulfuric acid was studied. The pKSH+ and log SH+/S or log SH2+2/SH+ values were determined by UV spectrophotometry.
R H, Manzo, M M, De Bertorello
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The Journal of Organic Chemistry, 2019
The first synthesis of isoxazole-4-carboxylic acid derivatives by domino isoxazole-isoxazole isomerization is reported. Fe(II)-catalyzed isomerization of 4-acyl-5-methoxy-/5-aminoisoxazoles (dioxane, 105 °C) leads to the formation of isoxazole-4-carboxylic esters and amides in good yields. 4-Formyl-5-methoxyisoxazoles give methyl oxazole-4-carboxylates
Anna V. Serebryannikova +3 more
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The first synthesis of isoxazole-4-carboxylic acid derivatives by domino isoxazole-isoxazole isomerization is reported. Fe(II)-catalyzed isomerization of 4-acyl-5-methoxy-/5-aminoisoxazoles (dioxane, 105 °C) leads to the formation of isoxazole-4-carboxylic esters and amides in good yields. 4-Formyl-5-methoxyisoxazoles give methyl oxazole-4-carboxylates
Anna V. Serebryannikova +3 more
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2008
Isoxazoles, benzisoxazoles, isoxazolines, and isoxazolidines are classes of heterocyclic compounds having a remarkable number of applications and are very versatile building blocks in organic synthesis. The major developments on the chemistry of these heterocycles reported in the literature from 1996 to 2006 are reviewed.
GIOMI, DONATELLA +2 more
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Isoxazoles, benzisoxazoles, isoxazolines, and isoxazolidines are classes of heterocyclic compounds having a remarkable number of applications and are very versatile building blocks in organic synthesis. The major developments on the chemistry of these heterocycles reported in the literature from 1996 to 2006 are reviewed.
GIOMI, DONATELLA +2 more
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Acta Crystallographica Section C Crystal Structure Communications, 1996
The title compound, ethyl 3-(9-anthryl)-5-methyl-4-isoxazolecarboxylate, C 21 H 17 NO 3 , possesses two planar ring systems that lie at 80° from coplanarity. The bond linking the two ring systems is 1.489 (3) A, indicating only partial conjugation between the two ring systems.
M. D. Mosher, N. R. Natale, A. Vij
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The title compound, ethyl 3-(9-anthryl)-5-methyl-4-isoxazolecarboxylate, C 21 H 17 NO 3 , possesses two planar ring systems that lie at 80° from coplanarity. The bond linking the two ring systems is 1.489 (3) A, indicating only partial conjugation between the two ring systems.
M. D. Mosher, N. R. Natale, A. Vij
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Isoxazole is a versatile five-membered heterocyclic compound that has attracted significant attention due to its diverse medicinal chemistry and material science applications. This chapter provides a comprehensive overview of synthetic methodologies for preparing isoxazole derivatives, including traditional approaches such as cyclization reactions and ...
Popat Mohite, Savita Tauro, Aarati Pawar
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Popat Mohite, Savita Tauro, Aarati Pawar
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