Results 191 to 200 of about 8,235 (246)

The discovery of isocycloseram: A novel isoxazoline insecticide

, 2021
Isocycloseram is a novel insecticide discovered at Syngenta Crop Protection. It is a new member of the isoxazoline class of insecticides, which acts as a noncompetitive antagonist of the invertebrate γ-aminobutyric acid (GABA) receptor at a site distinct
J. Cassayre, T. Smejkal, Judith Blythe, P. Hoegger, P. Renold, T. Pitterna, C. Prasanna, Helmars Smits, E. Godineau, Torsten Luksch, Guillaume Berthon, Girish K. Rawal, Rupesh E. Patre, M. Lal, Mohamed Boussemghoune, Simonetta Masala, Fabien Barreteau, Michael Flaeschel, J. Vogt, M. E. Qacemi   +19 more
semanticscholar   +1 more source

Discovery, development, chemical diversity and design of isoxazoline-based insecticides.

Bioorganic & Medicinal Chemistry, 2020
Isoxazoline is a 5-membered heterocycle present in the active compounds of many commercial veterinary anti-ectoparasitic products. The molecular target of isoxazolines is the inhibition of GABA-gated chloride channels in insects.
I. Gonçalves, Gustavo Machado das Neves, Luciano Porto Kagami, V. Eifler-Lima, A. Merlo   +4 more
semanticscholar   +1 more source

Photochemistry of condensed isoxazolines

Monatshefte für Chemie Chemical Monthly, 1994
The condensed bridged isoxazolines4 are rearranged on irradiation with a low-pressure mercury lamp exclusively into condensed derivatives of tetrahydropyridine5. The selectivity of the rearrangement is due to a stabilization of the biradical8 by the overlap of the radical-electrons with π-electrons of the C=C double bond and the heterocyclic ring ...
V. Ondruš, L'. Fišera, N. Prónayová
openaire   +1 more source

2‐Isoxazolines: A Synthetic and Medicinal Overview

ChemMedChem, 2020
AbstractIsoxazolines are nitrogen‐ and oxygen‐containing five‐membered heterocyclic scaffolds with extensive biological activities. This framework can be readily obtained in good to excellent yields through 1,3‐dipolar cycloaddition between nitrones with alkynes or allenes, aryl/alkyl halides, alkynes, and oxaziridines under mild conditions.
Gulshan Kumar, Ravi Shankar
openaire   +2 more sources

1,3-Dipolar cycloaddition, HPLC enantioseparation and docking studies of saccharin/isoxazole and saccharin/isoxazoline derivatives as selective carbonic anhydrase IX and XII inhibitors.

Journal of Medicinal Chemistry, 2020
Two series of saccharin/isoxazole and saccharin/isoxazoline hybrids were synthesised by 1,3-dipolar cycloaddition. The new compounds showed to be endowed with potent and selective inhibitory activity against the cancer-related human carbonic anhydrase ...
Melissa D'Ascenzio, D. Secci, S. Carradori, S. Zara, Paolo Guglielmi, R. Cirilli, M. Pierini, G. Poli, T. Tuccinardi, A. Angeli, C. Supuran   +10 more
semanticscholar   +1 more source

Isoxazolines and isoxazoles as factor Xa inhibitors

Bioorganic & Medicinal Chemistry Letters, 2000
3,4,5-Trisubstituted isoxazolines (2) and isoxazoles (3) were prepared and evaluated for their in vitro and in vivo antithrombotic efficacy. They were compared to 3,5,5-trisubstituted isoxazolines (1) for Factor Xa selectivity and potency. They were also compared in an arterio-venous (A-V) shunt model of thrombosis.
J R, Pruitt, D J, Pinto, M J, Estrella, L L, Bostrom, R M, Knabb, P C, Wong, M R, Wright, R R, Wexler   +7 more
openaire   +2 more sources

Design, synthesis and herbicidal evaluation of novel uracil derivatives containing an isoxazoline moiety.

Pest Management Science, 2020
BACKGROUND Glyphosate is the most widely used and successful herbicide discovered to date, but its utility is now threatened by the occurrence of several glyphosate-resistant weed species.
Jichun Yang, A. Guan, Qiao Wu, Dongliang Cui, Changling Liu   +4 more
semanticscholar   +1 more source

Asymmetric synthesis of chiral spiro bis(isoxazoline) and spiro (isoxazole–isoxazoline) ligands

Tetrahedron: Asymmetry, 2010
Abstract Asymmetric synthesis of novel chiral ligands, bis(isoxazoline) on a spiro[4.4]nonane scaffold and isoxazole–isoxazoline on a spiro[4.5]decane scaffold, has been achieved by utilizing an enantiomerically pure alcohol as the starting material.
Kazuhiro Takenaka, Toyohiro Nagano, Shinobu Takizawa, Hiroaki Sasai   +3 more
openaire   +1 more source

Synthesis of isoxazoline analogs of stellettins

Organic & Biomolecular Chemistry
(±)-Stellettin analogs featuring an isoxazoline ring were synthesized. Pharmacological evaluation of the analogs revealed that the α,β-unsaturated ketone structures in stellettins might be important to their cytotoxic activity.
Yuan Wang, Zhe Wang, Miao Zhuang, Xinyi Deng, Xiaoyu Liu, Xiaozhen Jiao, Ping Xie   +6 more
openaire   +2 more sources

Isoxazoline- and isoxazole-liquid crystalline schiff bases: A puzzling game dictated by entropy and enthalpy effects

, 2020
Two series of Schiff base (SB) liquid crystals (LC) containing the 5-membered rings isoxazoline or isoxazole were synthesized and characterized; 27 isoxazoline and 20 isoxazole compounds were obtained.
Luma Fritsch, L. A. Baptista, I. H. Bechtold, Guilherme D. E. Araujo, R. Mandle, A. Merlo   +5 more
semanticscholar   +1 more source