Results 91 to 100 of about 109,098 (297)

Functional characterization of hexokinases in the moss Physcomitrella patens [PDF]

, 2005
Carbohydrates are important nutrients and structural components in all living organisms. In plants they affect the developmental and metabolic processes throughout the plant life cycle.
Olsson, Tina
core  

Outcomes following exposure to drug interactions with ibrutinib in patients with chronic lymphocytic leukaemia

British Journal of Haematology, EarlyView.
Summary Ibrutinib is metabolized by cytochrome P450 3A (CYP3A) and poses challenges with drug interactions. We conducted a population‐based cohort study of Ontario residents aged ≥66 years who initiated ibrutinib for chronic lymphocytic leukaemia (CLL) to evaluate the frequency of potential drug interactions involving moderate/strong CYP3A inhibitors ...
Tuan Hoang, Matthew C. Cheung, David N. Juurlink, Kelvin K. W. Chan, Cindy Lau, Ning Liu, Husam Abdel‐Qadir, Anca Prica, Annette E. Hay, Abi Vijenthira, Lee Mozessohn   +10 more
wiley   +1 more source

Na,K-ATPase isozymes in colorectal cancer and liver metastases

Frontiers in Physiology, 2016
The goal of this study was to define Na,K-ATPase α and β subunit isoform expression and isozyme composition in colorectal cancer cells and liver metastases.
Marc eBaker Bechmann, Deborah eRotoli, Deborah eRotoli, Manuel eMorales, Manuel eMorales, María del Carmen eMaeso, María del Pino eGarcía, Julio eÁvila, Ali eMobasheri, Ali eMobasheri, Pablo eMartin-Vasallo   +10 more
doaj   +1 more source

IMPDH and GTP Metabolism in Cancer: Mechanisms, Regulation, and Translational Scope

Cancer Science, EarlyView.
This review provides a systematic summary of the current understanding of IMPDH biology, emphasizing its complex regulation and therapeutic relevance in cancer. We will outline key unresolved questions, including isozyme‐specific roles and mechanisms for escaping regulations, and propose mechanistic and translational strategies to design IMPDH‐targeted
Aki Ogawa‐Iio, Koh Takeuchi, Keita Shigemi, Michelle Jane Genoveso, Hiroaki Niitsu, Iemasa Koh, Yusei Ota, Keita Yamane, Takao Hinoi, Natsuki Osaka, Masashi Oshima, Tomohiro Ishikawa, Tomoyuki Mizuno, Manabu Natsumeda, Kensuke Tateishi, Rintaro Hashizume, Satoru Osuka, Susumu Goyama, Tomoharu Yasuda, Toshiya Senda, Atsuo T. Sasaki   +20 more
wiley   +1 more source

Proceedings of a workshop on Florida Spiny Lobster Research and Management, 24 August 1984 [PDF]

, 1985
Agenda, abstracts, bibliography of recent literature on spiny lobsters, and list of participants. Workshop held at the Florida State University Marine Laboratory, 24 August 1984. (25pp. W.F.
Herrnkind, William F.
core  

Activity of Cyclic AMP Phosphodiesterases and Adenylyl Cyclase in Peripheral Nerve after Crush and Permanent Transection Injuries [PDF]

, 1998
Recent studies demonstrate that cAMP levels are tightly controlled during demyelination and remyelination in Schwann cells as cAMP decreases to 8–10% of normal following both sciatic nerve crush or permanent transection injury and only begins to increase
Poduslo, Joseph F., Walikonis, Randall S.   +1 more
core   +1 more source

Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases

Cell Proliferation, EarlyView.
HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang, Yue‐Yue Wang, Ri Wen, Tie‐Ning Zhang, Ni Yang   +4 more
wiley   +1 more source

Aluminium induced esterase activity and isozyme pattern in barley root tip

Plant, Soil and Environment, 2005
Changes in the activity of esterase as well as changes in the viability of root cells and some growth parameters were analysed during cultivation of barley seedlings in the artificial substrate under Al stress conditions.
L. Tamás, J. Huttová, I. Mistrík, M. Šimonovičová, B. Široká   +4 more
doaj   +1 more source

Posttranslational modifications of phosphodiesterase type 4 enzymes represent novel points for therapeutic targeting

The FEBS Journal, EarlyView.
Enzymes from the phosphodiesterase type 4 family (PDE4) coordinate physiological events driven by the cyclic AMP s(cAMP) signaling pathway by tightly controlling cAMP dynamics in many cell types. Key to this strict regulation is the myriad of posttranslational modifications that alter PDE4 activity, cellular location, and binding partner selection ...
Madihah Hussain, Gonzalo S. Tejeda, George S. Baillie   +2 more
wiley   +1 more source

Potent Fluorescent Probe for Target‐Engagement Studies of Allosteric Pyruvate Kinase Modulators

Angewandte Chemie, Volume 137, Issue 42, October 13, 2025.
LumiPK, a novel environment‐sensitive fluorescent tracer, enables direct monitoring of allosteric ligand engagement with pyruvate kinase fused with nanoluciferase (Nluc), focusing on the liver isoform (PKL). In NanoBRET, and fluorescence indicator displacement assays, LumiPK shows high affinity and validates known allosteric modulators of PKL.
Oscar Nilsson, Anna P. Valaka, Liliana Håversen, Agnieszka Bogucka, István Köteles, Paul Brear, Mikael Rutberg, Anders Gunnarsson, Marko Hyvönen, Morten Grøtli   +9 more
wiley   +2 more sources