Results 121 to 130 of about 109,098 (297)

IA‐0130, a novel 3‐(1,3‐diarylallylidene)oxindole derivative, alleviates ovarian cancer via inhibiting IL‐6/gp130/STAT3 signalling

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 22, Page 5670-5689, November 2025.
Background and Purpose Dysregulation of the IL‐6/glycoprotein 130(gp130)/STAT3 signalling axis is implicated in several human diseases, particularly cancer. Notably, gp130, a single transducer of this signalling axis, is a target for ovarian cancer treatment. However, data regarding small‐molecule inhibitors of gp130 are lacking. Therefore, we aimed to
Sun‐Ae Park   +11 more
wiley   +1 more source

Diversity and genetic structure in natural populations of Hancornia speciosa var. speciosa Gomes in northeastern Brazil Diversidade e estrutura genética em populações naturais de Hancornia speciosa var. speciosa Gomes no nordeste do Brasil

open access: yesRevista Brasileira de Fruticultura, 2012
Hancornia speciosa Gomes is a fruit tree native from Brazil that belongs to Apocinaceae family, and is popularly known as Mangabeira. Its fruits are widely consumed raw or processed as fruit jam, juices and ice creams, which have made it a target of ...
Georgia Vilela Martins   +4 more
doaj  

Free Radicals in Health and Disease

open access: yesMedComm, Volume 6, Issue 10, October 2025.
Free radicals have dual roles that can either selectively create oxidative damages to transformed cells in treating proliferative diseases such as cancers and some dermatological disorders or boost the antioxidant system in treating degenerative diseases such as neurodegenerative disorder, joint degeneration, and metabolic conditions.
Xiaofeng Dai, Zizheng Huang, Ruohan Lyu
wiley   +1 more source

Diabetic Wound Repair: From Mechanism to Therapeutic Opportunities

open access: yesMedComm, Volume 6, Issue 10, October 2025.
Diabetic wound healing is compromised by chronic metabolic dysfunction that disrupts essential cellular processes. This review examines key predisposing factors, including neuropathy and vascular disease, characterizes dysfunction in critical cell types such as macrophages and fibroblasts, evaluates limitations of current models, compares established ...
Renyuan Wang   +5 more
wiley   +1 more source

Design, Synthesis, Biological Evaluation, and In Silico Study of Tetrahydropyridines as Prospective Monoamine Oxidase Inhibitors

open access: yesChemistryOpen, Volume 14, Issue 10, October 2025.
This work investigates the selective inhibition of MAO enzymes by varying the substitution of electron‐withdrawing and donating groups on the phenyl rings of tetrahydropyridines (4 a–4 o). Compounds 4 l and 4 n exhibit promising IC50 values of 0.40±0.05 and 1.01±0.03 μM against MAO‐A and MAO‐B, respectively.
Obaid ur Rehman Khan   +10 more
wiley   +1 more source

Relevamiento de la producción de lacasa en aislamientos de Colletotrichum (Ascomycota), agente causal de antracnosis de la Soja [PDF]

open access: yes, 2007
Colletotrichum truncatum es el hongo patógeno más comúnmente asociado con la antracnosis de soja. Aunque la enzima ligninolítica lacasa se relaciona con la patogenicidad de un amplio rango de hongos fitopatógenos, su rol biológico en la interacción ...
Gally, Marcela Edith   +3 more
core  

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