Results 81 to 90 of about 79,895 (267)

In Vitro and Clinical Evaluations of UGT1A1‐, P‐gp‐, OATP1B1‐, and BCRP‐Mediated Drug–Drug Interactions of Belumosudil, a Potent ROCK2 Inhibitor

The Journal of Clinical Pharmacology, Volume 65, Issue 8, Page 1026-1038, August 2025.
Abstract Belumosudil is an oral selective rho‐associated coiled‐coil containing protein kinase 2 inhibitor, approved as a treatment for chronic graft‐versus‐host disease. Prior clinical studies demonstrated that coadministration with strong CYP3A4 inducers or proton pump inhibitors requires dose modification of belumosudil.
Olivier Schueller, Lauren Lohmer, Felix Beck, Jeegar Patel, Jasminder Sahi   +4 more
wiley   +1 more source

Aluminium induced esterase activity and isozyme pattern in barley root tip

Plant, Soil and Environment, 2005
Changes in the activity of esterase as well as changes in the viability of root cells and some growth parameters were analysed during cultivation of barley seedlings in the artificial substrate under Al stress conditions.
L. Tamás, J. Huttová, I. Mistrík, M. Šimonovičová, B. Široká   +4 more
doaj   +1 more source

Isozyme-nonselective N-Substituted Bipiperidylcarboxamide Acetyl-CoA Carboxylase Inhibitors Reduce Tissue Malonyl-CoA Concentrations, Inhibit Fatty Acid Synthesis, and Increase Fatty Acid Oxidation in Cultured Cells and in Experimental Animals*

Journal of Biological Chemistry, 2003
Inhibition of acetyl-CoA carboxylase (ACC), with its resultant inhibition of fatty acid synthesis and stimulation of fatty acid oxidation, has the potential to favorably affect the multitude of cardiovascular risk factors associated with the metabolic ...
H. J. Harwood, S. Petras, Lorraine D. Shelly, L. Zaccaro, D. Perry, Michael Makowski, D. Hargrove, K. Martin, W. R. Tracey, J. Chapman, W. Magee, D. Dalvie, V. Soliman, W. Martin, C. Mularski, S. Eisenbeis   +15 more
semanticscholar   +1 more source

Protein aggregation and neurodegenerative disease: Structural outlook for the novel therapeutics

Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 8, Page 1314-1329, August 2025.
Abstract Before the controversial approval of humanized monoclonal antibody lecanemab, which binds to the soluble amyloid‐β protofibrils, all the treatments available earlier, for Alzheimer's disease (AD) were symptomatic. The researchers are still struggling to find a breakthrough in AD therapeutic medicine, which is partially attributable to lack in ...
Sharif Arar, Md Anzarul Haque, Rakez Kayed   +2 more
wiley   +1 more source

Cadmium induced changes in cell wall peroxidase isozyme pattern in barley root tips

Plant, Soil and Environment, 2006
Changes in peroxidase activity as well as isozyme peroxidase pattern were analyzed in five cell wall (CW) fractions of barley roots exposed to 1mM CdCl2for 48 and 72 h.
J. Huttová, I. Mistrík, M. Ollé-Šimonovičová, L. Tamás   +3 more
doaj   +1 more source

ISOZYMES OF LACTIC DEHYDROGENASE IN HUMAN TISSUES* [PDF]

, 1961
Elliot S. Vesell, Alexander G. Bearn
openalex   +3 more sources

A Genetic Map of Lettuce (Lactuca sativa L.) with Restriction Fragment Length Polymorphism, Isozyme, Disease Resistance and Morphological Markers.

Genetics, 1987
A detailed linkage map of lettuce was constructed using 53 genetic markers including 41 restriction fragment length polymorphism (RFLP) loci, five downy mildew resistance genes, four isozyme loci and three morphological markers.
B. Landry, R. Kesseli, B. Farrara, R. Michelmore   +3 more
semanticscholar   +1 more source

Bridging the gap in obesity research: A consensus statement from the European Society for Clinical Investigation

European Journal of Clinical Investigation, Volume 55, Issue 8, August 2025.
This consensus highlights critical research gaps in obesity epidemiology, phenotypic heterogeneity and clinical management, calling for advanced methodologies, collaborative strategies and innovative policies to mitigate the global obesity epidemic and its socio‐economic impacts.
Federico Carbone, Jean‐Pierre Després, John P. A. Ioannidis, Ian J. Neeland, Gabriella Garruti, Luca Busetto, Luca Liberale, Stefano Ministrini, Gemma Vilahur, Thomas H. Schindler, Maria Paula Macedo, Agostino Di Ciaula, Marcin Krawczyk, Andreas Geier, Gyorgy Baffy, Maria Felicia Faienza, Ilaria Farella, Nicola Santoro, Gema Frühbeck, Patricia Yárnoz‐Esquiroz, Javier Gómez‐Ambrosi, Emma Chávez‐Manzanera, Verónica Vázquez‐Velázquez, Jean‐Michel Oppert, Dimitrios N. Kiortsis, Paolo Sbraccia, Carmine Zoccali, Piero Portincasa, Fabrizio Montecucco   +28 more
wiley   +1 more source

Molecular Adjustment to a Social Niche: Brain Transcriptomes Reveal Divergent Influence of Social Environment on the Two Queen Morphs of the Ant Temnothorax rugatulus

Molecular Ecology, Volume 34, Issue 15, August 2025.
ABSTRACT Social insects form complex societies with division of labour between different female castes. In most species, a single queen heads the colony; in others, several queens share the task of reproduction. These different social organisations are often associated with distinct queen morphologies and life‐history strategies and occur in different ...
Marah Stoldt, Matteo Antoine Negroni, Barbara Feldmeyer, Susanne Foitzik   +3 more
wiley   +1 more source

Comparison of isozyme and RAPD patterns for analysis of the genetic relationship in Dendrobium crystallinum and D. sp. [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2006
The genetic relationship in two Dendrobium species which had similar morphology was analyzed using cluster analysis by UPGMA from their isozyme and RAPD data. It was found that dendrogram of eight isozyme systems could distinguish D. crystallinum from D.
Apavatjrut, P., Kuanprasert, N., Inthawong, S., Bundithya, W.   +3 more
doaj