Results 81 to 90 of about 84,898 (278)

Tumor promoter TPA activates Wnt/β-catenin signaling in a casein kinase 1-dependent manner. [PDF]

, 2018
The tumor promoter 12-O-tetra-decanoylphorbol-13-acetate (TPA) has been defined by its ability to promote tumorigenesis on carcinogen-initiated mouse skin.
Carson, Dennis A, Li, Shiyue, Liu, Shan-Shan, Lu, Desheng, Song, Jiaxing, Su, Zijie, Sun, Qi, Wang, Zhongyuan, Wei, Lei, Xia, Yuqing, Yu, Shubin, Zhao, Liang, Zhou, Liang   +12 more
core  

Fluoxetine: a case history of its discovery and preclinical development [PDF]

, 2014
Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N, Bergstrom RF, Bravo L, Bremner JD, Burrows GD, Chouinard G, Datla KP, Esther Berrocoso, Juan Antonio Mico, Kreiss DS, Laura Perez-Caballero, Lemberger L, Li Q, Lidia Bravo, Maj J, Nibuya M, Owens MJ, Rutter JJ, Sonia Torres-Sanchez, Stevens JC, Wong DT   +20 more
core   +2 more sources

Gap Analysis of Metabolic Conversions of Off‐Flavors and Antinutrients in Plant‐Based Substrates

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT To drastically reduce the carbon footprint of the food production chain, a major shift towards alternatives to conventional meat and dairy products is required. The use of plant‐based proteins is a promising route, but it also comes with challenges: Plant‐based proteins often contain antinutritional factors and off‐flavors, which can ...
Robin I. Kuijpers, Isabel O. de Moya Clark, Tomás Cavaco, Vivian Nemanič, Beatrice Tagliabue, Ainhoa Valero‐Abad, Wiebe M. Wennekers, Mengqiu Zhang, Koen Van Zwet, Sanne Abeln, Sofia Moco, Caroline E. Paul, Halima Mouhib, Richard A. Notebaart, Eddy J. Smid, Bas Teusink, Herwig Bachmann   +16 more
wiley   +1 more source

Esterase polymorphism marking cultivars of Manihot esculenta, Crantz

Brazilian Archives of Biology and Technology, 2004
Esterase isozymes were used to detected substrate-preference polymorphism in twenty cultivars of Manihot esculenta, and to show cultivar-specific variation of this species.
Adriana Gazoli Resende, Pedro Soares Vidigal Filho, Maria de Fátima P. S. Machado   +2 more
doaj   +1 more source

5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1. [PDF]

, 2018
The reaction of 5 S,15 S-dihydroperoxyeicosatetraenoic acid (5,15-diHpETE) with human 5-lipoxygenase (LOX), human platelet 12-LOX, and human reticulocyte 15-LOX-1 was investigated to determine the reactivity and relative rates of producing lipoxins (LXs).
Freedman, Cody, Green, Abigail R, Holinstat, Michael, Holman, Theodore R, Liu, Benjamin, Tena, Jennyfer, Tourdot, Benjamin E   +6 more
core   +3 more sources

Dexamethasone‐Mediated Regulation of CYP3A4 and UGTs in Human Hepatoma HuH‐7 Cells

Fundamental &Clinical Pharmacology, Volume 40, Issue 3, May 2026.
ABSTRACT Background The application of human hepatic cell lines to early drug discovery and development instead of human primary hepatocytes (HPHs) has been limited because of the low level of drug‐metabolizing enzymes (DMEs). Objective The study aimed to evaluate the effects of dexamethasone (DEX) treatment on DME expression, activities, and ...
Hana Yu, Song Hee Lee, Ji Hyeon Kim, Seung Jin Kim, Hee Eun Kang   +4 more
wiley   +1 more source

Biochemical evidence of gene transfer from the Mv genome of Aegilops ventricosa to hexaploid wheat [PDF]

, 1973
Endosperm protein and isozyme patterns of Unes derived from the ovoss [Tritioum turgidum (AABB) x Aegilops ventrioosa (DDMVMV)] x T_. aes tivum (AABBDD) were studied. Five bioohemioal oharaoters pvesent in Ae_. ventrioosa (DDM°M°), Ae_.
Delibes Castro, Angeles, García Olmedo, Francisco   +1 more
core   +1 more source

Tomato: a crop species amenable to improvement by cellular and molecular methods [PDF]

, 1989
Tomato is a crop plant with a relatively small DNA content per haploid genome and a well developed genetics. Plant regeneration from explants and protoplasts is feasable which led to the development of efficient transformation procedures.
A. Crossway, A. Guri, A. Hoekema, A. Kinshara, A. Morgan, A. Zelcer, A.H. Paterson, A.J. Framond De, A.L. Phillips, A.L. Phillips, A.R. Krol Van der, B. Baker, B. Baker, B. Hause, B. McClintock, B. Piechulla, B.A. Levenko, B.D. Harrison, B.L. Ward, B.P. Moens, B.R. Thomas, B.R. Thomas, B.S. Gill, B.S. Landry, B.S. Landry, B.S. Landry, C. Chang, C. Pieterse, C. Waldron, C.D. Riggs, C.E. Vallejos, C.E. Vallejos, C.J.S. Smith, C.M. Rick, C.M. Rick, C.M. Rick, C.M. Rick, C.M. Rick, C.M. Rick, C.M. Rick, C.M. Rick, C.M. Smith, C.P. Meredith, D. Boer De, D. Botstein, D. Shah, D. Zamir, D. Zamir, D. Zamir, D.A. Evans, D.A. Evans, D.M. Barker, D.M. Lonsdale, D.P. Barlow, D.W. Barton, D.W. Galbraith, E. Haute Van, E. Pichersky, E.A. Frankenberger, E.A. Frankenberger, E.A. Shahin, E.A. Shahin, E.C. Tigchelaar, F.J. Zapata, G. Gavazzi, G. Melchers, G. Schweizer, G.S. Khush, G.S. Khush, H.P. Mühlbach, I. Negrutiu, I.M. Greenblat, J. Botterman, J. Haseloff, J. Hille, J. Hille, J. Paszkowski, J. Phillips, J. Wijbrandi, J.D. Palmer, J.D. Palmer, J.D. Palmer, J.D. Palmer, J.F. Gusella, J.F. Gusella, J.F. Shepard, J.G. Atherton, J.H. Hawkes, J.I. Yoder, J.J. Fillatti, J.L. Bennetzen, J.M. van Montagu Schell, J.S. Beckmann, J.S. Beckmann, J.W. Maxon-Smith, J.W. Verna De, Jacoues Hille, K. Ohyama, K. Shinozaki, K. Umesono, K.A. Darden, K.K. Kartha, L. Herrera-Estrella, L. Herrera-Estrella, L. Marton, L.A. Miki, L.P. Hosticka, L.W. Handley, M. Block De, M. Buiatti, M. Buiatti, M. Cuozzo, M. Jongsma, M. Koornneef, M. Koornneef, M. Mutschler, M. S. Ramanna, M. Sibi, M. Soller, M. Vaeek, M. Wallroth, M. Ziv, M.A. O'Connell, M.A. O'Connell, M.A. O'Connell, M.A. O'Connell, M.A. Sluys Van, M.A. Stevens, M.A. Stevens, M.D. Bennett, M.L.M.C. Tan, M.L.M.C. Tan, M.R. Hanson, M.S. Ramanna, M.S. Ramanna, M.S. Ramanna, M.W. Bevan, M.W. Ganal, M.Y. Menzel, Maarten Koornneef, N.A. Zagorska, N.D. Young, N.D. Young, N.E. Tumer, N.V. Federoff, P. Little, P. Zambryski, P.E. McClean, P.F. Ambros, P.G. Smith, P.J.M. Elzen Van den, P.J.M. Elzen Van den, P.M. Gresshoff, Pim Zabel, R. Bernatzky, R. Bernatzky, R. Ecochard, R. Hain, R. Niedz, R.A. Bressan, R.A.J. Daelen Van, R.B. Flavell, R.B. Horsch, R.D. Locky, R.D. Shillito, R.S. Nelson, R.T. Fraley, S. Dellaporta, S. McCormick, S. Ohki, S.D. Tanksley, S.D. Tanksley, S.D. Tanksley, S.D. Tanksley, S.D. Tanksley, S.D. Tanksley, St.G. Rogers, T. Helentjaris, T. Helentjaris, T. Helentjaris, T.C. Osborn, T.L. Adams, T.M. Klein, U. Wienand, V. Padmanabhan, V.A. Hilder, W. Gottschalk, W. Gruissem, W.L. Gerlach, W.R. Sharp, Y.S. Chyi, Z. Koukolikova-Nicola, Z. Tabaeizadeh   +192 more
core   +3 more sources

Discovery and Evaluation of Cadmium‐Adapted Daphnia pulex Genotypes in a Region of Historical Mining Reveals Adaptation Protects the Germline From Cadmium‐Induced Mutations

Molecular Ecology, Volume 35, Issue 9, May 2026.
ABSTRACT Exposure to chemical pollutants can alter the rate and genome‐wide distribution of germline mutations. However, studies measuring the effects of chemical exposure on mutation rates and spectra have not considered the ecological and evolutionary backgrounds of the studied genotypes, which could influence the rates and patterns of germline ...
Nathan Keith, Stephen P. Glaholt, Craig E. Jackson, Kim Young, Karel De Schamphelaere, John K. Colbourne, Joseph R. Shaw   +6 more
wiley   +1 more source

Determination of Aldehyde Dehydrogenase (ALDH) Isozymes in Human Cancer Samples - Comparison of Kinetic and Immunochemical Assays

Molecules, 2002
A fluorimetric assay of aldehyde dehydrogenase isozymes, based on naphthaldehyde oxidation, is compared with Western Blotting analysis on several clinical samples obtained from surgery.
Dorota Borecka, Magdalena Blazejczyk, Jakub Golab, Jacek Wierzchowski, Piotr Wroczynski   +4 more
doaj   +1 more source