Results 81 to 90 of about 5,248,567 (304)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
, 2016 1 online resource (PDF). (2016). A polemical companion to Ethics of Life: Contemporary Iberian Debates. Hispanic Issues On Line Debates. Volume 7. Contributors.
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Journal of MultiDisciplinary Evaluation, 2005 This is a particularly exciting issue, for several reasons. First, we have an important paper by Tom Cook (describing what is special about the role of experiments, etc.) which goes a long way towards defining a compromise on the ‘causal wars’ issues, as I try to spell out in a few comments, and Jane Davidson discusses in her editorial.
openaire +6 more sources
, 2016 1 online resource (PDF, Contributors). (2016). The place of Hispanic linguistics and literary/cultural studies: current debates on liberal education. Hispanic Issues On Line Debates, Volume 6. Contributors.
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Вестник трансплантологии и искусственных органовObjective: to compare the remodeling features of polyurethane (PU) and bovine pericardium (BP) patches that have been implanted in a sheep carotid artery for 6 months. Materials and methods.
E. A. Senokosova +7 more
doaj +1 more source
In vitro study of a biological prosthetic valve for seamless fixation
Вестник трансплантологии и искусственных органов, 2018 Aim: to evaluate the manipulative properties of the system being developed for cardiac valve re-operation on an in vitro bovine heart model.Material and methods.
K. U. Klyshnikov +7 more
doaj +1 more source