Results 91 to 100 of about 34,312,534 (257)

A Qualitative Synthesis of Cyberattack Trends in Managed Service Providers: Analyzing Multi-Tenant Vulnerabilities and Mitigation Strategies

open access: yesInformation
Managed Service Providers (MSPs) have increasingly become prime targets for cyberattacks due to their privileged access across multiple client environments.
Shiva Ram Neupane   +2 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

BuySmarter

open access: yesTelehealth and Medicine Today, 2018
Session Description: BUYSMARTER is a transformative, data-driven initiative leveraging the collective purchasing power ($24B/year) of the U.S. Department of Health and Human Services (HHS) to secure lower prices, achieve operational efficiencies, and ...
Lori Ruderman, Kenneth Thomson
doaj   +2 more sources

A Framework for Knowledge Management System in the Cloud Computing Environment and Web 2.0

open access: yesIranian Journal of Information Processing & Management, 2018
Today, data, information and knowledge are very important assets for organizations and the effective management of knowledge is considered a way to gain and sustain a competitive advantage in a highly dynamic environment of the organizations.
Seyed Hossein Siadat   +1 more
doaj  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Quality of IT Enabled Services in Higher Education Insti-Tutions in Saudi Arabia [PDF]

open access: yes, 2016
The delivery of education has improved over time by using the IT enabled services, especially in the higher education institutes. The role of the IT enabled services to disseminate effective teaching has increased over time and still improving with a ...
Basit Shahzad, Romana Aziz
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

Enterprise Technology Services

open access: yes, 2014
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF caption (viewed on July 23, 2014)Mode of ...

core   +1 more source

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