Results 71 to 80 of about 34,312,534 (257)
Ciencia PolicialEl presente trabajo describe una metodología basada en la captura y el procesamiento de datos filtrados que han sido puestos a la venta en la Dark Web, una zona de internet con una alta prevalencia de contenido criminal.
Noelia Rico Pachón +2 more
doaj +1 more source
MOOC Cubes and Clouds - Cloud Native Open Data Sciences for Earth Observation [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information SciencesThe "Cubes and Clouds" Massive Open Online Course (MOOC) addresses the growing challenges and opportunities in Earth Observation (EO) data analysis posed by the exponential growth of satellite missions and data volumes.
P. J. Zellner +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Other title: Kansas Department for Aging and Disability Services Update; Other title: Update
, 2016 application/pdf; "August 5, 2016."; "Reporting Date 06/30/2016."; Presentation before the Kansas Legislature, Robert G. Bethell Joint Committee on Home and Community Based Services and KanCare Oversight, presented by the Kansas ...
Kansas. Department for Aging and Disability Services.
core +1 more source
BMC Pharmacology and Toxicology, 2018 Background Aging population, is a reality in many countries because of improvement in the health care, patient safety and other supplemental factors. Pharmacotherapy in this population must be evaluated due to their higher susceptibility to adverse drug ...
Faisal Shakeel +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
MULTIDISCIPLINARY OPEN SYSTEM TRANSFERRING KNOWLEDGE FOR R2B DEVELOPMENT
TASK Quarterly, 2017 Despite many efforts, there is still a serious problem in transferring knowledge from research to business. The problem is especially visible in Poland – the cooperation of R2B is ineffective.
HENRYK KRAWCZYK, PAWEŁ LUBOMSKI
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source