Results 51 to 60 of about 804,400 (340)
Humanities, 2017 L’articolo si propone di indagare il funzionamento della censura postale e dei tribunali militari durante la Grande Guerra attraverso il rapporto epistolare intercorso fra i sospettati di diserzione e i propri familiari, con particolare attenzione alle ...
Claudio Staiti
doaj +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Informes de la Construcción, 1961 El palacio de la Sociedad Nacional de Hidrocarburos se levanta muy próximo a la vía Emilia, sobre un solar de 20.000 m2, ocupando casi 3.000 m2 la superficie cubierta. La parte libre de terreno ha sido dedicada a pistas de acceso, estacionamiento, zonas verdes y edificio destinado a biblioteca.
openaire +5 more sources
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Court of Milan holds video sharing platforms liable for copyright infringement [PDF]
, 2011 On January 2011 and May 2011 the Court of Milan released two interesting decisions in Reti Televisive Italiane S.p.A. v Italia On Line S.r.l. (published on 7 June 2011) and Reti Televisive Italiane S.p.A. v Yahoo! Italia S.r.l. and Yahoo! Inc. (published
Bonadio, E., Santo, M.
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Molecular Oncology, EarlyView.Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef +10 more
wiley +1 more source
Molecular Oncology, EarlyView.In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella +18 more
wiley +1 more source
What is the Philology Author? [PDF]
, 2014 Este artículo pretende definir la filología de autor y, para ello, atenderá a su génesis, donde cobran especial importancia las figuras de Contini e Isella, a sus premisas básicas, que la diferencian de la crítica genética francesa y al radical ...
Italia, Paola, Raboni, Giulia
core
Tecnoscienza, 2013 What is the state of art of Science and Technology Studies in Italy? What happened in the last five years? In this paper, the departing President of STS Italia traces the main lines of research of STS scholars in Italy, highlighting the ways in which a scientific field (previously under-represented in the Italian scenario) has gained visibility and ...
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Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source