Results 31 to 40 of about 639,783 (293)
Hepatology, EarlyView., 2022 Natural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study. Abstract Background and Aims Alagille syndrome (ALGS) is a multisystem disorder, characterized by cholestasis. Existing outcome data are largely derived from tertiary centers, and real‐world data are lacking.
Shannon M. Vandriel +93 more
wiley +1 more source
Annales Universitatis Paedagogicae Cracoviensis. Studia de Cultura, 2017 L’articolo presenta diverse tendenze di esprimere i rapporti di caratterizzazione in italiano e russo, riconducibili non tanto alle differenze del sistema grammaticale, quanto all’uso comune condiviso dai parlanti.
Roman Govorukho
doaj +1 more source
Quaderns d'Italià, 2020 Este estudio trata la producción de rotacismos por hablantes sicilianos, cuyas lenguas nativas son el italiano y el dialecto siciliano. Se toman como muestra conversaciones con diferentes interlocutores. Como en muchas otras lenguas, la /r/ funciona como
Chiara Meluzzi, Chiara Celata
doaj +1 more source
Approximating the Smallest Spanning Subgraph for 2-Edge-Connectivity in Directed Graphs
, 2015 Let $G$ be a strongly connected directed graph. We consider the following three problems, where we wish to compute the smallest strongly connected spanning subgraph of $G$ that maintains respectively: the $2$-edge-connected blocks of $G$ (\textsf{2EC-B});
Georgiadis, Loukas +3 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
La La scrittura di un eretico corsaro. L’italiano di Pasolini saggista e pubblicista
Moderna Språk, 2023 Il contributo esamina dal punto di vista linguistico i testi raccolti da Pasolini in Empirismo eretico (1971) e negli Scritti corsari (1975). I due volumi comprendono saggi e articoli che hanno caratteristiche diverse (per tematiche, ampiezza, ecc.), ma
Paolo D'Achille
doaj +1 more source
Observations on daily Life in the communal town of Leopoli-Cencelle [PDF]
, 2017 The civitas of Leopoli-Cencelle, founded by Pope Leo IV (9th cent.), is located in the Tolfa Mountains on the northern edge of the Province of Rome.
Annoscia, GIORGIA MARIA
core +4 more sources
Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon +12 more
wiley +1 more source
Principali Accordi Internazionali [PDF]
, 2009 Testi dei principali Accordi Internazionali in materia di proprietà industriale disponibili in Italiano e ...
Lamandini, Marco
core