Results 91 to 100 of about 3,022,639 (245)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Review authors’ judgments about each risk of bias item using Cochrane risk of bias assessment.

Review authors’ judgments about each risk of bias item using Cochrane risk of bias assessment.
Jody C. Olson (17867144), Ram M. Subramanian (3170706)   +1 more
core   +1 more source

A Dual-Adversarial Learning Framework with Explicit Constraints for Two-Sided Fairness in Recommendation System

Open Information Science
Recommendation systems frequently exhibit two fundamental types of bias: user-side bias, where recommendations discriminate based on protected attributes such as gender, and item-side bias, where popular items dominate exposure irrespective of their ...
Karboua Sabrina, Harrag Fouzi, Meziane Farid   +2 more
doaj   +1 more source

An overview of differential item functioning in multistage computer adaptive testing using three-parameter logistic item response theory

Language Testing in Asia, 2017
As perfectly summarised by Ida Lawrence, “Testing is growing by leaps and bounds across the world. There is a realization that a nation’s well-being depends crucially on the educational achievement of its population.
Karim Sadeghi, Zainab Abolfazli Khonbi
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.

, 2016
Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
Christian Michael Gysin (3121881), Mark Loeb (248712), Danielle Vuichard Gysin (3121884), Dyda Dao (564112), Lyubov Lytvyn (3121887)   +4 more
core   +2 more sources

Exploring reporting quality of systematic reviews and Meta-analyses on nursing interventions in patients with Alzheimer’s disease before and after PRISMA introduction

BMC Medical Research Methodology, 2018
Background Systematic reviews (SRs) and meta-analyses (MAs) are distillation of current best available evidence, but are potentially prone to bias. The bias of SRs and MAs comes from sampling bias, selection bias and within study bias.
Xiao Sun, Xiaobin Zhou, Yan Yu, Haihua Liu   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Bias-Corrected Root Mean Square Deviation Estimators

Foundations
The root mean square deviation (RMSD) is a widely used item fit statistic in item response models. However, the sample RMSD is known to exhibit positive bias in small samples. To address this, seven alternative bias-corrected RMSD estimators are proposed
Alexander Robitzsch
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source