Results 91 to 100 of about 3,462,089 (291)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Linking Error Estimation in Fixed Item Parameter Calibration: Theory and Application in Large-Scale Assessment Studies

open access: yesFoundations
In fixed item parameter calibration (FIPC), an item response theory (IRT) model is estimated with item parameters fixed at reference values to estimate the distribution parameters within a specific group.
Alexander Robitzsch
doaj   +1 more source

The Estimation of Item Response Models with the lmer Function from the lme4 Package in R [PDF]

open access: yes
In this paper we elaborate on the potential of the lmer function from the lme4 package in R for item response (IRT) modeling. In line with the package, an IRT framework is described based on generalized linear mixed modeling. The aspects of the framework
Ivailo Partchev   +6 more
core  

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Daily item (New Orleans, La.) [PDF]

open access: yes, 1889
"Official journal of the city of New Orleans"Dolph Briscoe Center for American ...
City Item Printing
core   +1 more source

The reliability of six item bias indices

open access: yes, 1984
The reliabilities of six item bias indices were investigated for each of the eleven tests of the Iowa Tests of Basic Skills, using random samples of fifth-grade students.
Hoover, H. D., Kolen, Michael J.
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Exploring reporting quality of systematic reviews and Meta-analyses on nursing interventions in patients with Alzheimer’s disease before and after PRISMA introduction

open access: yesBMC Medical Research Methodology, 2018
Background Systematic reviews (SRs) and meta-analyses (MAs) are distillation of current best available evidence, but are potentially prone to bias. The bias of SRs and MAs comes from sampling bias, selection bias and within study bias.
Xiao Sun   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Item Nonresponse Bias [PDF]

open access: yes, 2015
The purpose of this study was to investigate the prevalence of item nonresponse bias among participants in the FSSE survey and its impact on the estimates of ten FSSE scale scores, by comparing item nonresponse patterns across faculty-level ...
BrckaLorenz, Allison, Chiang, Yi-Chen
core   +1 more source

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