Results 81 to 90 of about 367,195 (301)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Unbiased Analysis of Item-Specific Multi-Voxel Activation Patterns Across Learning
Frontiers in Neuroscience, 2018 Recent work has highlighted that multi-voxel pattern analysis (MVPA) can be severely biased when BOLD response estimation involves systematic imbalance in model regressor correlations.
Hannes Ruge +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
A Short Note on Aberrant Responses Bias in Item Response Theory
Frontiers in Psychology, 2019 Item response models often cannot calculate true individual response probabilities because of the existence of response disturbances (such as guessing and cheating).
Bing Jia, Xue Zhang, Zhemin Zhu
doaj +1 more source
Statistical Bias in Maximum Likelihood Estimators of Item Parameters [PDF]
Psychometrika, 1982 Asymptotic formulas are derived for the bias in the maximum likelihood estimators of the item parameters in the logistic item response model when examinee abilities are known. Numerical results are given for a typical verbal test for college admission.
openaire +1 more source
, 2015 The purpose of this study was to investigate the prevalence of item nonresponse bias among participants in the FSSE survey and its impact on the estimates of ten FSSE scale scores, by comparing item nonresponse patterns across faculty-level ...
BrckaLorenz, Allison, Chiang, Yi-Chen
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020 Introduction To understand the potential influence of diversity on the measurement of functional impairment in dementia, we aimed to investigate possible bias caused by age, gender, education, and cultural differences. Methods A total of 3571 individuals
Mark A. Dubbelman +20 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source