Results 111 to 120 of about 376,522 (308)

Bias Reduction in Robust Mean–Geometric Mean Linking via SIMEX

Algorithms
Robust mean–geometric mean (MGM) linking is a method for comparing the performance of two groups on a test involving dichotomous items and is particularly suited to settings with fixed and sparse differential item functioning (DIF).
Alexander Robitzsch
doaj   +1 more source

Understanding examinees’ item responses through cognitive modeling of response accuracy and response times [PDF]

, 2023
Susan E. Embretson
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

An Item Response Model for True-False Exams Based on Signal Detection Theory. [PDF]

Appl Psychol Meas, 2020
DeCarlo LT.
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Bias-Reduced Haebara and Stocking–Lord Linking

J
Haebara and Stocking–Lord linking methods are frequently used to compare the distributions of two groups. Previous research has demonstrated that Haebara and Stocking–Lord linking can produce bias in estimated standard deviations and, to a smaller extent,
Alexander Robitzsch
doaj   +1 more source

Approximating Bifactor IRT True-Score Equating With a Projective Item Response Model. [PDF]

Appl Psychol Meas, 2020
Kim KY, Cho UH.
europepmc   +1 more source

Simulation-based Bayesian inference for latent traits of item response models: Introduction to the ltbayes package for R [PDF]

, 2014
Timothy R. Johnson, Kristine M. Kuhn
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

SIMEX-Based and Analytical Bias Corrections in Stocking–Lord Linking

Analytics
Stocking–Lord (SL) linking is a popular linking method for group comparisons based on dichotomous item responses. This article proposes a bias correction technique based on the simulation extrapolation (SIMEX) method for SL linking in the 2PL model in ...
Alexander Robitzsch
doaj   +1 more source