Results 131 to 140 of about 20,299,108 (307)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

ITEM Grenseffectenrapportage 2017, Dossier 3: Sociale Zekerheid: Wijzigingsvoorstellen Verordening 883/2004 en 987/2009

open access: yes, 2017
De wijzigingsvoorstellen voor Coördinatieverordening 883/2004 en de ex ante ...
ITEM, Montebovi, Saskia
core  

Using the area between two item response functions to index differential item functioning : a generalized approach [PDF]

open access: yes, 1994
The area between two item response functions was used to construct two indicators of differential item functioning. The first indicator was designed from the integral of the difference of the two response functions across six standard deviations of ...
Penny, James A.   +1 more
core  

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

The application of measurement theory to tests in mathematics: a study of the goodness-of-fit of rasch model to the alis mathematics test [PDF]

open access: yes, 2003
The scores provided by the International Test of Developed Ability (ITDA) have been used as an alternative baseline for comparing the progress of students in the A-level Information System (ALIS) project of U.K.
Kwan, Siu Kam
core  

Bias-Corrected Fixed Item Parameter Calibration, with an Application to PISA Data

open access: yesStats
Fixed item parameter calibration (FIPC) is commonly used to compare groups or countries using an item response theory model with a common set of fixed item parameters.
Alexander Robitzsch
doaj   +1 more source

Past perspectives and new opportunities for the explanatory item response model. [PDF]

open access: yesAnn Dyslexia, 2020
Petscher Y   +3 more
europepmc   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Markov Chain Monte Carlo Estimation of Normal Ogive IRT Models in MATLAB [PDF]

open access: yes
Modeling the interaction between persons and items at the item level for binary response data, item response theory (IRT) models have been found useful in a wide variety of applications in various fields. This paper provides the requisite information and
Yanyan Sheng
core  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

open access: yesFEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos   +9 more
wiley   +1 more source

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