Results 151 to 160 of about 21,112,499 (262)
Extended Rasch Modeling: The eRm Package for the Application of IRT Models in R [PDF]
Item response theory models (IRT) are increasingly becoming established in social science research, particularly in the analysis of performance or attitudinal data in psychology, education, medicine, marketing and other fields where testing is relevant ...
Patrick Mair, Reinhold Hatzinger
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Which doctor? Combining vignettes and item response to measure doctor quality [PDF]
The authors develop a method in which vignettes-a battery of questions for hypothetical cases-are evaluated with item response theory to create a metric for doctor quality. The method allows a simultaneous estimation of quality and validation of the test
Das, Jishnu, Hammer, Jeffrey
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Mokken Scale Analysis in R [PDF]
Mokken scale analysis (MSA) is a scaling procedure for both dichotomous and polytomous items. It consists of an item selection algorithm to partition a set of items into Mokken scales and several methods to check the assumptions of two nonparametric item
L. Andries van der Ark
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Bayesian Estimation of MIRT Models with General and Specific Latent Traits in MATLAB [PDF]
Multidimensional item response models have been developed to incorporate a general trait and several specific trait dimensions. Depending on the structure of these latent traits, different models can be considered.
Yanyan Sheng
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Limited Information Goodness-Of-Fit Testing In Multidimensional Contingency Tables [PDF]
We introduce a family of goodness-of-fit statistics for testing composite null hypotheses in multidimensional contingency tables of arbitrary dimensions. These statistics are quadratic forms in marginal residuals up to order r.
ALBERTO MAYDEU
core
Item Response Model Adaptation for Analyzing Data from Different Versions of Parkinson's Disease Rating Scales. [PDF]
Pharm Res, 2019 Gottipati G +5 more
europepmc +1 more source