Modeling of Responses and Response Times with the Package cirt [PDF]
In computerized testing, the test takers' responses as well as their response times on the items are recorded. The relationship between response times and response accuracies is complex and varies over levels of observation.
Wilm van der Linden +2 more
core
Using the area between two item response functions to index differential item functioning : a generalized approach [PDF]
, 1994 The area between two item response functions was used to construct two indicators of differential item functioning. The first indicator was designed from the integral of the difference of the two response functions across six standard deviations of ...
Penny, James A. +1 more
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Comparing Robust Haberman Linking and Invariance Alignment
StatsLinking methods are widely used in the social sciences to compare group differences regarding the mean and the standard deviation of a factor variable. This article examines a comparison between robust Haberman linking (HL) and invariance alignment (IA ...
Alexander Robitzsch
doaj +1 more source
A Bayesian Generalized Explanatory Item Response Model to Account for Learning During the Test. [PDF]
Psychometrika, 2021 Lozano JH, Revuelta J.
europepmc +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
A new method for detecting differential item functioning in the Rasch model [PDF]
Differential item functioning (DIF) can lead to an unfair advantage or disadvantage for certain subgroups in educational and psychological testing. Therefore, a variety of statistical methods has been suggested for detecting DIF in the Rasch model.
Carolin Strobl +2 more
core
Item Response Model Validation of the German ICD-11 International Trauma Questionnaire for PTSD and CPTSD. [PDF]
Clin Psychol Eur, 2021 Christen D +3 more
europepmc +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source