Results 141 to 150 of about 376,522 (308)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

plink: An R Package for Linking Mixed-Format Tests Using IRT-Based Methods

Journal of Statistical Software, 2010
The R package plink has been developed to facilitate the linking of mixed-format tests for multiple groups under a common item design using unidimensional and multidimensional IRT-based methods.
Jonathan P. Weeks
doaj  

An Item Response Theory Model of Inter-Regional Collaboration for Transportation Planning in the United States [PDF]

, 2021
Soyoung Kim, Woo-Je Kim, Richard C. Feiock   +2 more
openalex   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Lost in Benchmarks? Rethinking Large Language Model Benchmarking with Item Response Theory [PDF]

Hongli Zhou, Han Huang, Ziqing Zhao, L.-K. Han, H X Wang, Kehai Chen, Muyun Yang, Wei Bao, Jianwei Dong, Bing Xu, Conghui Zhu, Hailong Cao, Tiejun Zhao   +12 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Random Item Response Model Approaches to Evaluating Item Format Effects

, 2018
Yongsang Lee, In‐Yong Park
openalex   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Item Response Model Adaptation for Analyzing Data from Different Versions of Parkinson's Disease Rating Scales. [PDF]

Pharm Res, 2019
Gottipati G, Berges AC, Yang S, Chen C, Karlsson MO, Plan EL.   +5 more
europepmc   +1 more source

Examining the relation of personality factors to substance use disorder by explanatory item response modeling of DSM-5 symptoms

, 2019
Fu Chen, Hongmei Yang, Okan Bulut, Ying Cui, Tao Xin   +4 more
openalex   +2 more sources