Results 61 to 70 of about 400,137 (262)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Comparing Different Specifications of Mean–Geometric Mean Linking
FoundationsMean–geometric mean (MGM) linking compares group differences on a latent variable θ within the two-parameter logistic (2PL) item response theory model.
Alexander Robitzsch
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
An application of item response theory to psychological test development
Psicologia: Reflexão e Crítica, 2016 Item response theory (IRT) has become a popular methodological framework for modeling response data from assessments in education and health; however, its use is not widespread among psychologists. This paper aims to provide a didactic application of IRT
Cristian Zanon +3 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Item Response Theory for trait assessment in randomized item pool for computer based test
Scientific AfricanThe rapid adoption of computer-based examinations (CBE) has raised concerns regarding fairness and reliability in assessing student performance. This study examines randomized test item fairness to test takers’ traits in CBE through the application of ...
Rhydal Esi Eghan +5 more
doaj +1 more source
DFIT: An R Package for Raju's Differential Functioning of Items and Tests Framework
Journal of Statistical Software, 2017 This paper presents DFIT, an R package that implements the differential functioning of items and tests framework as well as the Monte Carlo item parameter replication approach for producing cut-off points for differential item functioning indices ...
Víctor H. Cervantes
doaj +1 more source
BAYES MODAL ESTIMATION IN ITEM RESPONSE MODELS* [PDF]
ETS Research Report Series, 1985 ABSTRACTThis article describes a Bayesian framework for estimation in item response models, with two‐stage prior distributions on both item and examinee populations. Strategies for point and interval estimation are discussed, and a general procedure based on the EM algorithm is presented. Details are given for implementation under one‐, two‐, and three‐
openaire +2 more sources