Results 171 to 180 of about 13,591,879 (306)

Extreme Response Style: A Simulation Study Comparison of Three Multidimensional Item Response Models. [PDF]

Appl Psychol Meas, 2019
Leventhal BC.
europepmc   +1 more source

Estimation of Models in a Rasch Family for Polytomous Items and Multiple Latent Variables [PDF]

The Rasch family of models considered in this paper includes models for polytomous items and multiple correlated latent traits, as well as for dichotomous items and a single latent variable. An R package is described that computes estimates of parameters
Zhushan Li, Jeroen K. Vermunt, Carolyn J. Anderson   +2 more
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Joint Item Response Models for Manual and Automatic Scores on Open-Ended Test Items. [PDF]

Psychometrika
Bengs D, Brefeld U, Kroehne U, Zehner F.
europepmc   +1 more source

Ignoring a Multilevel Structure in Mixture Item Response Models: Impact on Parameter Recovery and Model Selection. [PDF]

Appl Psychol Meas, 2018
Lee WY, Cho SJ, Sterba SK.
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Bayesian Estimation of Generalized Log-Linear Poisson Item Response Models for Fluency Scores Using brms and Stan. [PDF]

J Intell
Myszkowski N, Storme M.
europepmc   +1 more source

Refining the assessment of disrupted maternal communication: Using item response models to identify central indicators of disrupted behavior. [PDF]

Dev Psychopathol, 2019
Haltigan JD, Madigan S, Bronfman E, Bailey HN, Borland-Kerr C, Mills-Koonce R, Lyons-Ruth K.   +6 more
europepmc   +1 more source