Results 191 to 200 of about 14,062,107 (346)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Weighted Majorization Algorithms for Weighted Least Squares Decomposition Models [PDF]

For many least-squares decomposition models efficient algorithms are well known. A more difficult problem arises in decomposition models where each residual is weighted by a nonnegative value.
Groenen, P.J.F., Kiers, H.A.L., Giaquinto, P.   +2 more
core  

A regularised latent‐class item response model for detecting measurement non‐invariance in ordinal response scales

Gabriel Wallin, Qi Huang
openalex   +1 more source

HBMIRT: A SAS macro for estimating uni- and multidimensional 1- and 2-parameter item response models in small (and large!) samples. [PDF]

Behav Res Methods
Wagner W, Zitzmann S, Hecht M.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Which doctor? Combining vignettes and item response to measure doctor quality [PDF]

The authors develop a method in which vignettes-a battery of questions for hypothetical cases-are evaluated with item response theory to create a metric for doctor quality. The method allows a simultaneous estimation of quality and validation of the test
Das, Jishnu, Hammer, Jeffrey
core  

Classical test theory and item response theory validation of a building design and modeling fundamentals test in vocational education

Yolanda Putri Nami, Fahmi Rizal, Muhammad Giatman, Ari Syaiful Rahman Arifin   +3 more
openalex   +2 more sources

A Representation-Learning Item Response Model for Identifying Behaviorally Important Actions in PIAAC Process Data [PDF]

Junyeong Park, Daeun Hwangbo, Seyoung Park, Ick Hoon Jin, Minjeong Jeon   +4 more
openalex   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

THE EFFECT OF TEST LENGTH, SAMPLE SIZE, AND ITEM RESPONSE THEORY MODELS ON GENERALIZABILITY THEORY

Priarti Megawanti, Siti Alifah, Sulastry Pardede, Erna Megawati, Wardani Rahayu   +4 more
openalex   +2 more sources