Results 211 to 220 of about 14,062,107 (346)
ForceChoice: Forced-Choice Modeling Based on Item Response Theory and Cognitive Diagnostic Models [PDF]
Haijiang Qin, Lei Guo
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High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Laplace-PSN-IRT: Uncertainty Quantification for Neural Item Response Theory Models of LLM Benchmarks [PDF]
Juan Francisco, Mandujano Reyes
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In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
IRTC: Marginal Maximum Likelihood Estimation for Item Response Models [PDF]
Kunxiang Ma
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Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Tirt R Package: A Tutorial on Item Response and Testlet Response Theory Modeling
Jiawei Xiong +3 more
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Comparative Evaluation of Three Item Response Theory Models within an Educational Measurement System: Application to the Moroccan National Student Assessment Program in Science [PDF]
Sara Bouhazzama, Mohammed Salah Chiadmi
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This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source

