Results 41 to 50 of about 6,731 (280)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Fastest walk control of quadruped robots for trot gait by using torque redundancy of leg joints
Nihon Kikai Gakkai ronbunshu, 2016 A way of deriving the fastest walk pattern of quadruped robots for trot gait is developed and installed into a practical robot system. Two support legs and the body are modeled as a five-link manipulator and each swinging leg is modeled as a two link ...
Yuhei SUZUKI +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Practical Iterated Fill Synthesis for CMP Uniformity
, 2000 We propose practical iterated methods for layout density control for CMP uniformity, based on linear programming, Monte-Carlo and greedy algorithms. We experimentally study the tradeoffs between two main filling objectives: minimizing density variation ...
Alexander Zelikovsky +3 more
core +1 more source
Iterated decoding of modified product codes in optical networks:[invited] [PDF]
, 2009 Appendix I of the standard ITU-T G.975 contains several codes that have been proposed for improved performance of optical transmission. While the original application was submarine cables, the codes are now also used in terrestrial systems where ...
Justesen, Jørn, J. Justesen
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Fourier frequencies in affine iterated function systems
, 2007 We examine two questions regarding Fourier frequencies for a class of iterated function systems (IFS). These are iteration limits arising from a fixed finite families of affine and contractive mappings in R-d, and the IFS refers to such a finite system
Dutkay, Dorin Ervin +1 more
core +2 more sources
Freidlin-Wentzell LDPs in path space for McKean-Vlasov equations and the Functional Iterated Logarithm Law [PDF]
, 2019 We show two Freidlin-Wentzell Large Deviations Principles for McKean-Vlasov Stochastic Differential Equations (MV-SDEs) in path space topologies using techniques addressing directly the presence of the law in the coefficients and avoiding altogether ...
Salkeld, William +2 more
core +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source