Results 51 to 60 of about 1,234,026 (278)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
BMC GenomicsGenome-wide CRISPR sgRNA libraries have emerged as transformative tools to systematically probe gene function. While these libraries have been iterated over time to be more efficient, their large size limits their use in some applications.
Sebastian Lukasiak +8 more
doaj +1 more source
IEEE AccessThe Multiple Traveling Salesman Problem with Backup Coverage (mTSP-BC) is a vehicle routing variant in which all vehicles must remain within a maximum pairwise distance at every instant during their traversal, imposing spatiotemporal interdependence ...
Jonathan Cardozo Maciel +2 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
ITER Global Stability Limits [PDF]
Fusion Technology, 1991 The MHD stability limits to the ITER operational space have been examined with the PEST ideal stability code. Constraints on ITER operation have been examined for the nominal operational scenarios and for possible design variants. Rather than rely on evaluation of a relatively small number of sample cases, the approach has been to construct an ...
Hogan, J. T., Uckan, N. A.
openaire +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
MathematicsIn this paper, we examine a sequence of uncountable iterated function systems (U.I.F.S.), where each term in the sequence is constructed from an uncountable collection of contraction mappings along with a linear and continuous operator.
Ion Mierluș–Mazilu, Lucian Niță
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Cooperative Equilibria in Iterated Social Dilemmas
, 2013 The implausibility of the extreme rationality assumptions of Nash equilibrium has been attested by numerous experimental studies with human players. In particular, the fundamental social dilemmas such as the Traveler’s dilemma, the Prisoner’s dilemma ...
Polukarov, Maria +8 more
core +1 more source