Results 61 to 70 of about 1,234,026 (278)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

A two-loop four-point form factor at function level

Journal of High Energy Physics
Recently, the maximally-helicity-violating four-point form factor for the chiral stress-energy tensor in planar N $$ \mathcal{N} $$ = 4 super Yang-Mills was computed to three loops at the level of the symbol associated with multiple polylogarithms.
Lance J. Dixon, Shuo Xin
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The first–order factorizable contributions to the three–loop massive operator matrix elements AQg(3) and ΔAQg(3)

Nuclear Physics B
The unpolarized and polarized massive operator matrix elements AQg(3) and ΔAQg(3) contain first–order factorizable and non–first–order factorizable contributions in the determining difference or differential equations of their master integrals.
J. Ablinger, A. Behring, J. Blümlein, A. De Freitas, A. von Manteuffel, C. Schneider, K. Schönwald   +6 more
doaj   +1 more source

Integrated Assortment–Shelf Optimization under Substitution and Space Elasticity: A Hybrid Memetic Algorithm [PDF]

Industrial Management Journal
Objective: This study maximizes expected retail profit by jointly optimizing product assortment and shelf-space allocation, considering substitution effects and space-elastic demand.
Ali Ebrahimi Kordler, Saleh Mansouri, Farzad Bahrami   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Core-Level Modeling and Frequency Prediction for DSP Applications on FPGAs

International Journal of Reconfigurable Computing, 2015
Field-programmable gate arrays (FPGAs) provide a promising technology that can improve performance of many high-performance computing and embedded applications.
Gongyu Wang, Greg Stitt, Herman Lam, Alan George   +3 more
doaj   +1 more source

Systematic analysis of non-structural protein features for the prediction of PTM function potential by artificial neural networks.

PLoS ONE, 2017
Post-translational modifications (PTMs) provide an extensible framework for regulation of protein behavior beyond the diversity represented within the genome alone.
Henry M Dewhurst, Matthew P Torres
doaj   +1 more source

Realizability interpretation of PA by iterated limiting PCA [PDF]

Mathematical Structures in Computer Science, 2014
For any partial combinatory algebra (PCA for short) $\mathcal{A}$, the class of $\mathcal{A}$-representable partial functions from $\mathbb{N}$ to $\mathcal{A}$ quotiented by the filter of cofinite sets of $\mathbb{N}$ is a PCA such that the representable partial functions are exactly the limiting partial functions of $\mathcal{A}$-representable ...
openaire   +3 more sources

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source