Results 91 to 100 of about 48,863 (239)

Strategy for Identifying Rational Sensitivity Analysis Using PBPK Modeling for Precipitant Drug–Drug Interaction Predictions

Clinical Pharmacology &Therapeutics, Volume 119, Issue 2, Page 314-317, February 2026.
Physiology Based Pharmacokinetic (PBPK) modeling is an established essential tool for predicting and/or analyzing drug–drug interactions (DDI). Uncertainty and variability associated with in vitro determined DDI‐related parameters have often been considered a limitation for predicting PBPK‐DDIs.
Kunal S. Taskar, Pradeep Sharma, Karen Rowland Yeo   +2 more
wiley   +1 more source

Itraconazole promotes melanoma cells apoptosis via inhibiting hedgehog signaling pathway-mediated autophagy

Frontiers in Pharmacology
BackgroundItraconazole, a widely used antifungal medication, has shown potential in inhibiting tumor growth and reducing angiogenesis. However, its role in melanoma tumor growth remains insufficiently explored.
Shunqiao Jin, Shunqiao Jin, Xiaojiao Liu, Xiaojiao Liu, Lingqin Cai, Lingqin Cai, Jiayu Yan, Ling Li, Hongjun Dong, Yuxue Gao, Xicong Zhu, Cong Zhang, Xuezhu Xu   +12 more
doaj   +1 more source

Itraconazole: What clinicians should know?

, 2017
Our purpose in assembling this paper is 2-fold. First, we hope to review in-depth the properties on itraconazole pellet-capsules and what clinicians should know when considering oral itraconazole and discuss the potential value of treating superficial ...
P. De Doncker, S. Pande, U. Richarz, N. Garodia   +3 more
semanticscholar   +1 more source

Antifungal susceptibility testing ofExophialaspp.: a head-to-head comparison of amphotericin B, itraconazole, posaconazole and voriconazole [PDF]

, 2009
Annette W. Fothergill, Michael G. Rinaldi, Deanna A. Sutton   +2 more
openalex   +1 more source

Terbinafine‐Resistant Trichophyton Dermatophytosis in Australia

Australasian Journal of Dermatology, EarlyView.
Thuvarahan Jegathees, Zachary P. Holmes, Catherine Martin, Cindy Kalai, Catherine Voutier, Denis Spelman, Gemma Robertson, Johannes S. Kern   +7 more
wiley   +1 more source

Efficacy, Safety and Biological Characteristics of Formulation Based on Essential Oil Against Co‐Infections of Herpes Simplex Virus‐1 and Candida albicans

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
Essential oils with anti‐HSV‐1 activity were identified through literature review and tested against Candida to develop a formulation for co‐infections. The blend was assessed for anti‐inflammatory properties, allergenic potential via standardized BAT, and overall antiviral efficacy.
Maura Di Vito, Domiziana Coggiatti, Marilena La Sorda, Stefania Garzoli, Giulia Lombardini, Debora Talamonti, Scilla Pizzarelli, Abdesselam Zhiri, Margherita Cacaci, Riccardo Torelli, Maurizio Sanguinetti, Francesca Bugli   +11 more
wiley   +1 more source

Hyalohyphomycotic chronic rhinosinusitis caused by Microascus cirrosus in a cat

Veterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract A 13‐year‐old, male, neutered, indoor‐only, domestic long‐haired cat was presented with an 8‐month history of sneezing and a 2‐month history of epistaxis. Computed tomography demonstrated an irregular contrast‐enhancing soft tissue opacity within both nasal cavities and osteolysis of surrounding bony structures.
Leonel Frutuoso, Samuel Fowlie, Sean Haugland, Emma Corbett, Christopher Scudder   +4 more
wiley   +1 more source

Exploring the therapeutic mechanism of itraconazole combined with ritonavir on Candida albicans infection through network pharmacology and molecular docking

Frontiers in Pharmacology
BackgroundAutophagy induced by itraconazole and ritonavir was found involved in the pathogenesis of C. albicans. This study was designed to explore the possible molecular mechanism of itraconazole and ritonavir in the treatment of Candida albicans ...
Yiyang Feng, Wenli Feng, Jing Yang, Yan Ma   +3 more
doaj   +1 more source

Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells [PDF]

, 2015
Sarah A. Head, Wei Shi, Liang Zhao, Kirill Gorshkov, Kalyan Kumar Pasunooti, Yue Chen, Zhiyou Deng, Ruo-Jing Li, Joong Sup Shim, Wenzhi Tan, Thomas Härtung, Jin Zhang, Yingming Zhao, Marco Colombini, Jun O. Liu   +14 more
openalex   +1 more source

Chronic cavitary pulmonary histoplasmosis treated with isavuconazole after a hypersensitivity reaction to itraconazole

Medical Mycology Case Reports
Chronic cavitary pulmonary histoplasmosis requires prolonged treatment with itraconazole. However, hypersensitivity reactions to itraconazole, though rare, pose a challenge due to limited data on the efficacy and cross-reactivity of the newer azoles.
Miguel E. Cervera-Hernandez, Sunit P. Jariwala   +1 more
doaj   +1 more source