Results 101 to 110 of about 48,966 (221)
Idiopathic AIDS enteropathy and treatment of gastrointestinal opportunistic pathogens. [PDF]
, 2009 Diarrhea in patients with acquired immune deficiency syndrome (AIDS) has proven to be both a diagnostic and treatment challenge since the discovery of the human immunodeficiency virus (HIV) virus more than 30 years ago.
Cello, John P, Day, Lukejohn W
core
Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation
MedComm – Oncology, Volume 5, Issue 2, June 2026.The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong +4 more
wiley +1 more source
Bilateral Ulcers in Protothecosis: A Diagnostic Challenge
International Journal of Dermatology, EarlyView.
Waratchaya Panjapakkul +4 more
wiley +1 more source
Effects of Renal and Hepatic Impairment on the Pharmacokinetics of Zilurgisertib
British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1339-1351, May 2026.Aim Small‐molecule activin receptor‐like kinase‐2 inhibitor zilurgisertib (INCB000928) is under investigation in a pivotal trial for the treatment of fibrodysplasia ossificans progressiva (FOP), an ultrarare genetic condition. This analysis assessed effects of renal and hepatic impairment on zilurgisertib pharmacokinetics.
Yan‐ou Yang +5 more
wiley +1 more source
Medical Mycology Case ReportsChronic cavitary pulmonary histoplasmosis requires prolonged treatment with itraconazole. However, hypersensitivity reactions to itraconazole, though rare, pose a challenge due to limited data on the efficacy and cross-reactivity of the newer azoles.
Miguel E. Cervera-Hernandez +1 more
doaj +1 more source
Clinical Case Reports, Volume 14, Issue 5, May 2026.ABSTRACT Fusarium spp. are opportunistic fungal pathogens, with an increasing incidence of infection observed in immunocompromised populations. Due to the non‐specific clinical manifestations of cutaneous Fusarium infections, they are often misdiagnosed or overlooked.
Yulin Wang +9 more
wiley +1 more source
Pharmaceutical Compounding in Veterinary Medicine: Suspension of Itraconazole
PharmaceuticsItraconazole is a drug used in veterinary medicine for the treatment of different varieties of dermatophytosis at doses between 3–5 mg/kg/day in cats. Nevertheless, in Spain, it is only available in the market as a 52 mL suspension at 10 mg/mL.
Gema J. Cabañero-Resta +6 more
doaj +1 more source
The Journal of Clinical Pharmacology, Volume 66, Issue 5, May 2026.Abstract Impact of concomitant medications (conmeds) on the safety of the investigational agent is often evaluated using subgroup analyses for safety events in patients who received the conmed versus those who did not. Here, we highlight the potential biases and inconclusive results that can arise from such analyses, using talazoparib and P ...
Diane Wang +4 more
wiley +1 more source
The Journal of Clinical Pharmacology, Volume 66, Issue 5, May 2026.Abstract A recent article in this journal by Wu et al presented a comprehensive model for the maturation of paracetamol clearance from birth to adulthood using pooled plasma and urinary data of the parent drug and its metabolites from 298 subjects. The modeling showed that the oxidative bioactivation to hepatotoxic metabolite N‐acetyl‐p‐benzoquinone ...
Markku Pasanen, Risto O. Juvonen
wiley +1 more source