Results 91 to 100 of about 37,692 (229)

Formulation and Characterization of Itraconazole as Nanosuspension Dosage Form for Enhancement of Solubility

Iraqi Journal of Pharmaceutical Sciences, 2019
Itraconazole is a triazole antifungal given orally for the treatment of oropharyngeal and vulvovaginal candidiasis, for systemic infections including aspergillosis, candidiasis,  and for the prophylaxis of fungal infections in immunocompromised patients.
Asmaa M. Rashid, Shaimaa N. Abdal-Hammid
doaj   +1 more source

Treatment of invasive aspergillosis with itraconazole

, 1989
PURPOSE: Invasive aspergillosis in the immunocompromised host is one of the most difficult therapeutic problems. Itraconazole, a new oral triazole, is inhibitory as well as fungicidal against Aspergillus species in vitro. It is active against Aspergillus
Stevens, D.A., Denning, D.W.; id_orcid, Hansen, L.H., Tucker, R.M.   +3 more
core   +1 more source

Exploring the therapeutic mechanism of itraconazole combined with ritonavir on Candida albicans infection through network pharmacology and molecular docking

Frontiers in Pharmacology
BackgroundAutophagy induced by itraconazole and ritonavir was found involved in the pathogenesis of C. albicans. This study was designed to explore the possible molecular mechanism of itraconazole and ritonavir in the treatment of Candida albicans ...
Yiyang Feng, Wenli Feng, Jing Yang, Yan Ma   +3 more
doaj   +1 more source

Lipid-itraconazole interaction in lipid model membranes

, 1991
Itraconazole, a lipophilic, fungal sterol-biosynthesis inhibitor, does not disturb membrane organization parameters measured by differential scanning calorimetry and infrared spectroscopy. Conformational analysis studies suggest that the molecular volume
J-M Ruysschaert, Goormaghtigh, Erik, Vanden Bossche, H, E Goormaghtigh, R Brasseur, Ruysschaert, Jean Marie, H Vanden Bossche, P H Duquenoy, Brasseur, Robert, Marichal, P, P Marichal, Duquenoy, Philippe   +11 more
core   +1 more source

Phytochemical Composition and Bioactivity of Elsholtzia strobilifera (Benth.) Benth Essential Oil With Spectral Characterisation of Pinocarvone Using NMR Techniques

Flavour and Fragrance Journal, Volume 41, Issue 6, Page 1538-1551, November 2026.
Elsholtzia strobilifera (Benth.) EO: in‐depth chemical and biological investigation. ABSTRACT Species of the genus Elsholtzia (Lamiaceae) have been traditionally used in folk medicine and are known for their diverse biological properties. However, the chemical composition and bioactivity of the essential oil from Elsholtzia strobilifera (Benth.) Benth.
Priyanka Bhatt, Pooja Bargali, Gunja Sah, G. C. Shah, Ravendra Kumar, Stefania Garzoli, Maneesha Pathak, Archana N. Sah   +7 more
wiley   +1 more source

Role of itraconazole in haematology/oncology

, 2003
The antifungal agents most frequently used in prophylaxis and treatment are amphotericin B (and its new lipid forms) and azoles such as fluconazole, itraconazole, and more recently voriconazole. This review assesses the role of itraconazole in paediatric
Atra, A. A., Pandya, Naushira, Pandya, N. A., Pinkerton, C. R., Riley, U., Riley, U, Pinkerton, C R, Atra, A A, N A Pandya   +8 more
core   +1 more source

Desenvolvimento e validação de metodologia analítica para determinação de itraconazol em produtos farmacêuticos por CLAE Development and validation of the methodology for evaluation of itraconazole in pharmaceutical products by HPLC

Química Nova, 2007
Itraconazole is a synthetic antifungal drug administered orally with a broad spectrum of activity against mycotic infections. The present work consists of the development and validation of analytical methodology for evaluation of itraconazole in ...
Edith Cristina Laignier Cazedey, Roberta de Cássia Pimentel Azevedo, Érika de Fátima Silva, Magali Benjamim de Araújo   +3 more
doaj   +1 more source

Design Considerations for Polymer–Deep Eutectic Solvent Hybrid Systems for Transdermal Drug Delivery

Journal of Applied Polymer Science, Volume 143, Issue 40, October 20, 2026.
Deep eutectic solvents (DESs) act as tunable, green excipients that modulate polymer structure–property relationships to enhance drug solubility, skin permeation, stability, and controlled release. Through hydrogen‐bond interactions, DES–polymer hybrid systems enable improved transdermal performance, offering a rational, design‐driven platform for ...
Madhavi Kailas Kapale, Madhur Kulkarni, Pranav J. Shah, Furqan A. Maulvi   +3 more
wiley   +1 more source

Itraconazole and inhaled fluticasone causing hypothalamic–pituitary–adrenal axis suppression in adults with cystic fibrosis

, 2013
BackgroundAlthough there have been case reports of hypothalamic–pituitary–adrenal (HPA) axis suppression in patients with cystic fibrosis (CF) caused by the combination of oral itraconazole and inhaled fluticasone, to date no study has assessed the ...
Gilchrist, Francis J
core   +1 more source

The effect of mild and moderate hepatic impairment on the pharmacokinetics, safety and tolerability of balcinrenone

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3656-3665, October 2026.
Abstract Aim Balcinrenone (previously AZD9977) is a novel selective non‐steroidal mineralocorticoid receptor antagonist (MRA) with a differential mechanism of action relative to approved MRAs. The aim of this trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone in participants with mild and moderate hepatic impairment ...
Anna L. Eriksson, Deeyen Karsanji, Bonifride Tuyishimire, Joanna Parkinson, Maria Heijer, Tadeusz Pawlik, Judith Hartleib‐Geschwindner, Maria Leonsson‐Zachrisson, Hans Ericsson   +8 more
wiley   +1 more source