Results 121 to 130 of about 48,863 (239)

Management of Tinea Capitis in children under 10 kg : Results from a French multicentre study

open access: yes
Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 2, Page e146-e150, February 2026.
A. Cornillault   +39 more
wiley   +1 more source

Navigating Solute Carrier Transporters—A Comprehensive Review of Functionalized Small Molecule Probes for Target Identification and Characterization

open access: yesMedicinal Research Reviews, Volume 46, Issue 1, Page 238-271, January 2026.
ABSTRACT Solute carrier transporters (SLCs) are integral membrane proteins that play pivotal roles in maintaining cellular homeostasis by mediating the transport of a diverse range of substrates across cell membranes. With their involvement in fundamental physiological processes such as nutrient uptake, neurotransmitter signaling, and drug transport ...
Majlen A. Dilweg   +3 more
wiley   +1 more source

Characterizing Apixaban Pharmacokinetics Through Physiologically‐Based Pharmacokinetic Modeling: Critical Role of Biliary Secretion and Enterohepatic Circulation in Humans

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.
ABSTRACT Apixaban, a factor Xa inhibitor, is a direct oral anticoagulant with a well‐balanced elimination; it is eliminated evenly via feces, urine (with no active secretion), and as metabolites after oral administration. The common understanding is that biliary secretion and enterohepatic circulation (EHC) of apixaban are limited in humans, and that ...
Toshiaki Tsuchitani   +3 more
wiley   +1 more source

Mobile Cone‐Beam CT‐Guided Transbronchial Cryobiopsy of a Penicillium Granuloma via the Right Post‐Eparterial Bronchus

open access: yesRespirology Case Reports, Volume 14, Issue 1, January 2026.
A post‐eparterial bronchus is a rare anatomical variant that can predispose to infection due to secretion stasis, especially in susceptible patients. Navigating this challenging airway can be achieved by the combination of an ultrathin bronchoscope for optimal access and mobile cone beam CT for definitive ‘tool‐in‐lesion’ confirmation.
Sze Shyang Kho   +3 more
wiley   +1 more source

Imidazolium‐Based Ionic Liquids as Antifungal and Antibiofilm Agents Against Candida tropicalis

open access: yesChemistrySelect, Volume 11, Issue 4, 28 January 2026.
Candida sp. biofilms, particularly those formed on catheters, represent a major clinical challenge. This study evaluates ionic liquids using an experimental biofilm model, demonstrating significant antifungal activity and biofilm disruption, supporting their potential application as alternative strategies for device‐associated infection control ...
Giovanna de Jesus Agostinetto   +4 more
wiley   +1 more source

Critical evaluation of real‐world evidence of repurposable medicines in the Alzheimer's disease drug development pipeline using a target trial emulation

open access: yesAlzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 1, January/March 2026.
Abstract INTRODUCTION Repurposing Food and Drug Administration (FDA)‐approved drugs could accelerate treatment development for Alzheimer's disease (AD). METHODS Using the MarketScan claims database (2011 to 2020), we applied a trial emulation approach in two base cohorts: (1) individuals with mild cognitive impairment (MCI cohort) and (2) individuals ...
Reina Tonegawa‐Kuji   +10 more
wiley   +1 more source

The Inhibitory Effects of Zinc Oxide Nanoparticles on Clinical Isolates of Malassezia in Dogs

open access: yesVeterinary Medicine and Science, Volume 12, Issue 1, January 2026.
Zinc oxide nanoparticles inhibit the growth and virulence of Malassezia pachydermatis clinical isolates from dogs. ZnO NPs exhibit potent fungicidal activity at low concentrations (MIC 3.90–7.81 ppm) and significantly downregulate the expression of Phospholipase A2 and Aspartyl proteinase genes, key virulence factors. This demonstrates the potential of
Alaleh Vazifehdust   +5 more
wiley   +1 more source

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