Results 91 to 100 of about 17,544 (219)
Food and Agricultural Immunology, 2019 The mode of action is the basis for the rational design of the novel agrochemicals. 3-(4-Methyl-1,2,3-thiadiazolyl)-6-trichloromethyl [1,2,4]triazolo [3,4-b][1,3,4]thiadiazole (YZK-C22) is a novel fungicide candidate.
Bin Zhao +8 more
doaj +1 more source
Quantitative profiling brain proteomes revealed mitochondrial dysfunction in Alzheimer’s disease
Molecular Brain, 2019 Mitochondrial dysfunction is a key feature in both aging and neurodegenerative diseases including Alzheimer’s disease (AD), but the molecular signature that distinguishes pathological changes in the AD from healthy aging in the brain mitochondria remain ...
Sunil S Adav +2 more
doaj +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.ABSTRACT Background The serine/threonine kinase AKT is a key regulator of glucose and energy metabolism. Prevailing dogma suggests that AKT is an obligate intermediate for glucose uptake in all metabolic tissues and that impaired AKT signalling is a major molecular driver of insulin resistance in obesity.
Natasha Jaiswal +5 more
wiley +1 more source
PLoS ONE, 2014 Shotgun proteomic methods involving iTRAQ (isobaric tags for relative and absolute quantitation) peptide labeling facilitate quantitative analyses of proteomes and searches for useful biomarkers.
Magdalena Luczak +2 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2017 Background/Aims: Clinical reports on adverse reactions that result from Polygonum multiflorum (PM) and its preparations, especially regarding liver injury, have recently received widespread attention.
Longfei Lin +7 more
doaj +1 more source
New Phytologist, Volume 251, Issue 4, Page 1909-1929, August 2026.A working model for GLYCOGEN SYNTHASE KINASE 3‐mediated phosphorylation of FLOWERING CONTROL LOCUS A in the regulation of brassinosteroid signaling and rice growth and development. Summary Brassinosteroid (BR) signaling plays a critical role in rice (Oryza sativa L.) grain development.
Jiaqi Zhang +14 more
wiley +1 more source
Supplemental Table 2 Proteins identified by iTRAQ proteomics
, 2023 Proteins identified by iTRAQ ...
Shuanggang Hu (5438381)
core +1 more source
Reconceptualizing Aplastic Anemia—Seed, Worm, Soil
Journal of Clinical Laboratory Analysis, Volume 40, Issue 14, July 2026.Aplastic anemia (AA) encompasses a group of hematological syndromes often misdiagnosed, resulting in a decrease in the overall blood cell count and representing a form of bone marrow failure. We reinterpret AA based on the “seed, worm, and soil” doctrine.
Xintong Xu +4 more
wiley +1 more source
Comparison of iTRAQ and SWATH in a clinical study with multiple time points
Clinical Proteomics, 2018 Background Advances in mass spectrometry have accelerated biomarker discovery in many areas of medicine. The purpose of this study was to compare two mass spectrometry (MS) methods, isobaric tags for relative and absolute quantitation (iTRAQ) and ...
Antti Jylhä +7 more
doaj +1 more source
Mass spectrometry proteomics for studying mitostasis
Protein Science, Volume 35, Issue 7, July 2026.Abstract Maintaining mitochondrial integrity and function is fundamental to cellular homeostasis. Cells rely on coordinated protein quality control (QC) systems—including intricate chaperone‐protease networks, the ubiquitin‐proteasome system, and cytosolic surveillance pathways—that together form a dynamic, cell‐wide mitostasis network governing the ...
Lakshita Sharma +5 more
wiley +1 more source