Results 51 to 60 of about 25,211 (209)

Isobaric tags for relative and absolute quantitation in identifying proteins for clozapine treatment response in patients with schizophrenia: A preliminary study

open access: yesTaiwanese Journal of Psychiatry, 2021
Objective: Schizophrenia is a mental disorder characterized by reduced social engagement, abnormal emotional expression, and a lack of motivation. Isobaric tags for relative and absolute quantitation (iTRAQ) are a novel proteomic technique. In this study,
Chin- Chuen Lin   +3 more
doaj   +1 more source

Pyridoxal Reprograms Peroxisomal Hydrogen Peroxide Metabolism to Induce Lethal Oxidative Stress in Ovarian Cancer

open access: yesiMetaMed, EarlyView.
Pyridoxal (PL) exhibits the strongest anti‐tumor activity within the vitamin B6 family, demonstrating significant ovarian cancer cell‐killing efficacy in vivo, in vitro, and in patient‐derived organoid (PDO) models. The anti‐tumor mechanism involves PL inducing a shift in peroxisome dynamics towards fission, promoting peroxisome proliferation, and ...
Ruonan Li   +12 more
wiley   +1 more source

iTRAQ-based proteomics reveals novel biomarkers of osteoarthritis [PDF]

open access: yesBiomarkers, 2013
We performed comprehensive proteomic analyses of articular cartilage by using the isobaric tags for relative and absolute quantitation (iTRAQ) method, and searched for candidate biomarkers for osteoarthritis (OA).Articular cartilage was collected from patients with OA or femoral neck fracture for the control group. Molecular variations were detected by
Ikeda, Daiki   +3 more
openaire   +2 more sources

Proteomic Analysis of Emodin Treatment in Neuropathic Pain Reveals Dysfunction of the Calcium Signaling Pathway

open access: yesJournal of Pain Research, 2021
Peng Chen,1 Dongsheng Lin,2 Chen Wang,2 Cuiwen Song,1 Wenjing Wang,1 Jinglian Qu,1 Zhibing Wu2 1Basic Medical School, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, People’s Republic of China; 2First Clinical Medical School ...
Chen P   +6 more
doaj  

Quantitative proteomics analysis of proteins involved in alkane uptake comparing the profiling of Pseudomonas aeruginosa SJTD-1 in response to n-octadecane and n-hexadecane. [PDF]

open access: yesPLoS ONE, 2017
While many data are available on genes encoding proteins for degradation of hydrocarbons in bacteria, the impact of alkane on transporter protein expression is unclear.
Xuefeng Zhou   +3 more
doaj   +1 more source

Evolutionary descent of prion genes from a ZIP metal ion transport ancestor [PDF]

open access: yes, 2009
In the more than 20 years since its discovery, both the phylogenetic origin and cellular function of the prion protein (PrP) have remained enigmatic.
David Westaway   +4 more
core   +1 more source

Protein Profiling of Arabidopsis Roots Treated With Humic Substances: Insights Into the Metabolic and Interactome Networks [PDF]

open access: yes, 2018
Background and Aim: Humic substances (HSs) influence the chemical and physical properties of the soil, and are also known to affect plant physiology and nutrient uptake.
Antonio Masi   +9 more
core   +4 more sources

Lymph‐based liquid biopsy: Current progress and future potential

open access: yesInterdisciplinary Medicine, EarlyView.
Recent evidence under the revised Starling principle indicates that lymph‐based liquid biopsies may offer superior diagnostic performance over blood‐based counterparts in certain clinical scenarios, such as early‐stage solid tumor detection. Currently, various biomarkers within the lymphatic system show significant diagnostic potential for a range of ...
Dongdong Liu   +6 more
wiley   +1 more source

Screening of serum biomarkers of preeclampsia by proteomics combination with bioinformatics

open access: yesHypertension in Pregnancy, 2019
Objective: To screen for novel predictive serum markers of preeclampsia (PE). Method: Blood samples were collected from seven women with PE and five with healthy pregnancies.
Yuee Ling, Jie Su, Jie Lin, Sumei Wang
doaj   +1 more source

Protein glycosylation in lung cancer from a mass spectrometry perspective

open access: yesMass Spectrometry Reviews, EarlyView.
Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi   +2 more
wiley   +1 more source

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