Results 111 to 120 of about 34,586 (301)

Form flows function: Learner‐centered game Re‐design in a STEM classroom

British Educational Research Journal, EarlyView.
Abstract Re‐designing games facilitates interest‐driven learning and immerses learners in systems thinking. However, there are limited studies exploring how the form and function of tabletop games influence learners' design decisions and learning experiences. To address this gap, we conducted a mixed‐methods study in a STEM classroom in western Canada.
Farzan Baradaran Rahimi, Beaumie Kim, Shima Dadkhahfard   +2 more
wiley   +1 more source

Deciphering the catalytic and pharmacological mechanisms of Coptis chinensis herbzymes to renovate intestinal microenvironment for colitis alleviation

BMEMat, EarlyView.
The synthesized CCzymes possess both antioxidant enzyme activity and pharmacological properties inherent to Coptis chinensis. By their antioxidant enzyme activity, CCzymes can attenuate oxidative stress within the inflammatory region of ulcerative colitis (UC), while their pharmacological activity acts on macrophage polarization and the intestinal ...
Zhichao Deng, Can Li, Yujie Zhang, Yuanyuan Zhu, Chenxi Xu, Bowen Gao, Mingxin Zhang, Martina H. Stenzel, Kelong Fan, Mingzhen Zhang, Yanyan Jiang   +10 more
wiley   +1 more source

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source

Hypoxia-Exosome Mesenchymal Stem Cells Therapy Reduces Interleukin-6 Levels and CD86 Expression

MCBS (Molecular and Cellular Biomedical Sciences)
Background: UVB exposure activates type 1 macrophages (CD86) and increases IL-6, both contributing to collagen loss. exosome hypoxia mesenchymal stem cells (EH-MSC) has anti-inflammatory properties, suggesting its potential role in modulating CD86 ...
Adelia Bayu Isfandiari, Agung Putra, Eko Setiawan   +2 more
doaj   +1 more source

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, EarlyView.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source

Candidate Gene Variants Linked to Brown Rot Susceptibility in the European Plum Genome

Agronomy
European plum (Prunus domestica) is among the most important stone fruits cultivated worldwide. However, its production is significantly affected by fungal brown rot disease, caused by Monilinia spp.
Raminta Antanynienė, Monika Kurgonaitė, Vidmantas Bendokas, Birutė Frercks   +3 more
doaj   +1 more source

Network of automated vehicles: the AutoNet 2030 vision [PDF]

, 2014
electronic proceedingsInternational audienceAutoNet2030 - Co-operative Systems in Support of Networked Automated Driving by 2030 - is a European project connecting two domains of intensive research: cooperative systems for Intelligent Transportation ...
Bonnabel, Silvère, de La Fortelle, Arnaud, Diemer, Sébastien, Festag, Andreas, Grégoire, Jean, Llatser, Ignacio, Marjovi, Ali, Martinoli, Alcherio, Moutarde, Fabien, Qian, Xiangjun, Sjöberg, Katrin   +10 more
core  

Integrated spherical nucleic acid nanoreactor mobilizes targeted PD‐L1 proteolysis and cuproptosis for robust breast cancer immunotherapy

BMEMat, EarlyView.
This study provides an integrated spherical nucleic acid nanoreactor (denoted as AMCuD) for targeted PD‐L1 degradation and chemo‐dynamically enhanced cuproptosis to synergically elicit robust immunotherapy against the triple‐negative breast cancer (TNBC) growth, recurrence and metastasis.
Ningxi Li, Honglin Huang, Qianyi Zeng, Li Zeng, Ziman Yang, Jinyang Shen, Shun Li, Hong Yang, Yiyao Liu, Chunhui Wu   +9 more
wiley   +1 more source

Eco‐Innovation, Economic Complexity, and Sustainability: A Bibliometric and Systematic Literature Review

Business Strategy and the Environment, EarlyView.
ABSTRACT This study systematizes the literature on eco‐innovation and economic complexity, aiming to understand how the sophistication of productive structures shapes countries' capacity to develop environmentally responsible innovations, and how eco‐innovation may, in turn, influence productive sophistication.
Gregory Matheus Pereira de Moraes, Diogo Ferraz   +1 more
wiley   +1 more source

On the Capacity of V2X Communication Networks to Support the Delivery of Emerging C-ITS Services: A Case Study on an Irish Motorway

Information
Roadside communication networks with Cooperative Intelligent Transport Systems (C-ITSs) offer services that aim to enhance traffic management and road safety.This paper presents a comprehensive scalability study of C-ITSs to support a deployment of Day 1
Arif Hossan, Md Noor-a-Rahim, Cormac J. Sreenan, Piraba Navaratnam, Shobanraj Navaratnarajah, Thomas Allen, David Laoide-Kemp, Aisling O’Driscoll   +7 more
doaj   +1 more source