Results 71 to 80 of about 35,748 (242)

A Cascaded DNA Nanocircuit for Multi‐Signal‐Responsive Precision siRNA Delivery in Cancer Therapy

Advanced Science, EarlyView.
A cascaded dual‐AND logic DNA nanocircuit is engineered to respond to three tumor‐specific signals in a sequential manner: extracellular acidic pH, membrane‐overexpressed nucleolin (NCL), and intracellular glutathione (GSH). This programmable system selectively releases siPARP1 in glioblastoma (GBM), effectively silencing PARP1 and reversing TMZ ...
Yan Zhao, Yufei Lan, Min‐Goo Lee, Jinjun He, Yueran Pan, Eunji Kim, Xin Fu, Sungwook Jung, Wanxia Lu, Jinyue Fan, Haoxiang Chen, Yuanbo Zhao, Yuling Xu, Jong Seung Kim, Chao Zhang   +14 more
wiley   +1 more source

Characterization and Selection of Lycium barbarum Cultivars Based on Physicochemical, Bioactive, and Aromatic Properties

Horticulturae
Goji berries (Lycium barbarum L.) are considered a functional food due to their high content of bioactive compounds with demonstrated health benefits. This study evaluated four cultivars (G3, G4, G5, and G7) grown under Mediterranean climate conditions ...
Juan Carlos Solomando González, María José Rodríguez Gómez, María Ramos García, Noelia Nicolás Barroso, Patricia Calvo Magro   +4 more
doaj   +1 more source

Defect‐Engineered BiO2‐X Nanosheets Mediate Sono‐Thermomechanical ECM Remodeling for Hepatocellular Carcinoma Immunotherapy

Advanced Science, EarlyView.
Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian, Shen Zhang, Bolin Wu, Yichi Chen, Haitao Shang, Haoyan Tan, Chunyue Wang, Weichen Xu, Huixiong Xu, Haohao Yin, Wen Cheng   +10 more
wiley   +1 more source

In vitro and in vivo double-enhanced suicide gene therapy mediated by generation 5 polyamidoamine dendrimers for PC-3 cell line

World Journal of Surgical Oncology, 2012
Background One of the most frequently used and efficient suicide gene therapies for prostate cancer is HSV-TK/GCV system, but its application has been limited due to lack of favorable gene vector and the reduction of "bystander effect".
Chen Yue, Wang Gang, Kong Deling, Zhang Zhihong, Yang Kuo, Liu Ranlu, Zhao Weiming, Xu Yong   +7 more
doaj   +1 more source

A State‐Gated Metallo‐DNAzyme Framework Programs Tumor Stress Vulnerability Through Metabolic Licensing

Advanced Science, EarlyView.
A tumor‐state‐gated metallo‐DNAzyme framework integrates miR‐21/APE1‐responsive GLUT1 silencing with Ca/Cu‐partitioned metal–nucleic acid assembly and cystine loading. The framework first weakens glucose‐dependent metabolic buffering and then amplifies copper‐ and disulfide‐associated stress, converting tumor metabolic adaptation into programmable ...
Xiaodong Ma, Lingyun He, Xinru Wang, Yuanyuan Wei, Chengcheng Li, Jiaqi Yan, Weijian Sun, Xian Shen, Hongbo Zhang   +8 more
wiley   +1 more source

Preparation and anti-tumor activity of natural product genistein imidazole derivatives

Results in Chemistry
Genistein, a natural isoflavone, exhibits potential anti-tumor properties but suffers from weak cytotoxicity that limits its clinical application. To improve its antitumor activity, five genistein imidazole/triazole derivatives (G1–G5) were designed and ...
Jingyi Peng, Haijun Hao, ChunYing Li, Xi Yan   +3 more
doaj   +1 more source

Specificity of French Bean (Phaseolus vulgaris L.) Genotypes and Rhizobium phaseoli Strains to Establish Symbiotic N-fixation in Inceptisols of Varanasi, Uttar Pradesh, India

International Journal of Bio-Resource and Stress Management, 2023
A pot experiment consisted of 15 treatment combinations of 5 genotypes of Phaseolus vulgaris L. (G1=HUR 15, G2= IC 14919, G3=DARL 1136, G4=DARL 1434 and G5=PI 175822) and 2 strains of Rhizobium leguminosarum biovar phaseoli along with a control (I0 ...
Janardan Yadav
doaj  

Epigenetic Reactivation of TNFRSF19 Suppresses Mitophagy and Sensitizes Triple‐Negative Breast Cancer to Doxorubicin

Advanced Science, EarlyView.
TNFRSF19 is an epigenetically silenced regulator of mitophagy in triple‐negative breast cancer. TNFRSF19 deficiency activates the TGFBR1–SMAD3–PINK1 axis to promote mitophagy and confer doxorubicin resistance, whereas decitabine‐mediated restoration of TNFRSF19 suppresses mitophagy and enhances doxorubicin sensitivity, revealing a targetable epigenetic–
Shiyang Liu, Chenguang Liu, Weihong Zheng, Xiaofei Tong, Zhengwei Gui, Zonghong Lu, Sun Ieong, Lin Zhang   +7 more
wiley   +1 more source

ITS‐G5 performance improvement and evaluation for vulnerable road user safety services

IET Intelligent Transport Systems, 2017
Cooperative intelligent transportation system (C‐ITS) allows to improve safety of vehicles through communications between vehicles and infrastructure. C‐ITS may also improve the safety of vulnerable road users (VRUs), but work on this issue is still in an early stage.
Scholliers Johan, Kujanpää Kaisa, Valta Mikko, Jutila Mirjami   +3 more
openaire   +2 more sources

Ultrasound‐Activated Nanoinhibitors Blocking the Chemo‐Immune Checkpoint to Overcome Chemotherapy‐Induced Immune Resistance

Advanced Science, EarlyView.
A sono‐responsive chemo‐immune checkpoint nanoinhibitor (Sono‐TT8) co‐delivering TPZ chemotherapy and siXkr8 simultaneously kills tumor cells and blocks PS externalization, reversing chemotherapy‐induced immunosuppression and enhancing antitumor immunity. ABSTRACT Breast cancer features an immunosuppressive tumor microenvironment following chemotherapy
Yunfan Liu, Chier Du, Leilei Zhu, Hongjin An, Shengzhe Hou, Yi Lan, Xuemei Tang, Min Xu, Peng Luo, Hua Teng, Hao Yang, Xun Guo, Jianli Ren, Zhiyi Zhou   +13 more
wiley   +1 more source