Results 81 to 90 of about 34,014 (241)

Magneto‐NIR‐II‐Programmed Cascade Nanozymes Unlocking Blood–Brain Barrier Translocation and Autophagic Resistance in Glioblastoma

Advanced Science, EarlyView.
Magneto‐NIR‐II‐programmed NFSH nanozymes integrate magnetic blood–brain barrier (BBB) translocation, CD44 targeting, multimodal imaging, and cascade catalytic therapy for glioblastoma. Alternating magnetic fields and NIR‐II irradiation amplify ferroptosis, release H2S, suppress autophagic and mitophagic repair, and reshape the immune microenvironment ...
Ruocan Liu, Yundi Wu, Shuai Zhang, Hongjuan Zhao, Jiping Zheng, Shiyang Shao, Jianqiang Chen, Xilong Wu   +7 more
wiley   +1 more source

Hypoxia-Exosome Mesenchymal Stem Cells Therapy Reduces Interleukin-6 Levels and CD86 Expression

MCBS (Molecular and Cellular Biomedical Sciences)
Background: UVB exposure activates type 1 macrophages (CD86) and increases IL-6, both contributing to collagen loss. exosome hypoxia mesenchymal stem cells (EH-MSC) has anti-inflammatory properties, suggesting its potential role in modulating CD86 ...
Adelia Bayu Isfandiari, Agung Putra, Eko Setiawan   +2 more
doaj   +1 more source

A C‐Nucleoside Analogue of Cordycepin With High Metabolic Stability and Potent Anti‐Psoriatic Activity via Microneedle Delivery

Advanced Science, EarlyView.
This work identified CPD3a as a potent, stable C‐nucleoside cordycepin derivative. When formulated into microneedle array for topical treatment, it ameliorated psoriasis by rebalancing immunity and enhancing antioxidant defenses. ABSTRACT Psoriasis is a chronic inflammatory disorder characterized by immune dysregulation and epidermal hyperplasia ...
Wenfang Pan, Xinyue Shao, Yuanchen Zhong, Xujie Sun, Lixuan Yin, Zongyan He, Tianqun Lang, Yuanchao Xie   +7 more
wiley   +1 more source

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

Ribofuranose-based GalNAc-conjugated siRNA enhances the liver-targeted delivery and elicits robust RNAi-mediated gene silencing

Molecular Therapy: Nucleic Acids
The N-acetylgalactosamine (GalNAc)-conjugate delivery platform has emerged as a pivotal enabling technology for the clinical translation of oligonucleotide therapeutics.
Ze-Ao Huang, Zhen-Min Li, Jie Wang, Guang-Shen Ji, Zhong-Cai Gao, Ai-Fu Chen, Zhi-Kang Tian, Fei Yu, Geng-Shen Song   +8 more
doaj   +1 more source

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source

Candidate Gene Variants Linked to Brown Rot Susceptibility in the European Plum Genome

Agronomy
European plum (Prunus domestica) is among the most important stone fruits cultivated worldwide. However, its production is significantly affected by fungal brown rot disease, caused by Monilinia spp.
Raminta Antanynienė, Monika Kurgonaitė, Vidmantas Bendokas, Birutė Frercks   +3 more
doaj   +1 more source

Magnetoelectric BaTiO3/CoFe2O4 Thin‐Film Meshes for Neuronal Differentiation

Advanced Science, EarlyView.
We engineer an epitaxial BaTiO3/CoFe2O4 magnetoelectric mesh that overcomes boundary‐induced mechanical clamping. Progressively reducing the mechanical constraint, from substrate‐clamped to PDMS‐transferred and ultimately freestanding, enhances magnetic‐to‐electric transduction and strengthens magnetoelectric coupling.
Mathieu Mirjolet, Hao Ye, Abderrahim Lahlahi Attalhaoui, Donghoon Kim, Vitaly Pustovalov, Elric Zhang, Marc Tudela‐Pi, Bastian Gebauer, Juan Bautista Carda Castelló, Anton Guimerà‐Brunet, Josep Puigmartí‐Luis, Xiang‐Zhong Chen, Minsoo Kim, Salvador Pané   +13 more
wiley   +1 more source

On the Capacity of V2X Communication Networks to Support the Delivery of Emerging C-ITS Services: A Case Study on an Irish Motorway

Information
Roadside communication networks with Cooperative Intelligent Transport Systems (C-ITSs) offer services that aim to enhance traffic management and road safety.This paper presents a comprehensive scalability study of C-ITSs to support a deployment of Day 1
Arif Hossan, Md Noor-a-Rahim, Cormac J. Sreenan, Piraba Navaratnam, Shobanraj Navaratnarajah, Thomas Allen, David Laoide-Kemp, Aisling O’Driscoll   +7 more
doaj   +1 more source

Atomic‐Scale Tracing of Lithium Trapped in Copper Current Collectors

Advanced Energy Materials, EarlyView.
Does lithium diffuse into the copper current collector during cycling in lithium‐metal batteries? This study unveils, at the atomic scale, that lithium is trapped at grain boundaries and junctions, already after only one plating/stripping cycle. After three and more cycles, the copper foil surface becomes nanocrystalline and oxidized.
Tong Li, Carlo Franke, Ziyuan Lyu, Omair Ashfaq, Mervyn Soans, Mohsen Sotoudeh, Thomas Diemant, Jun Xia, Aleksander Kostka, Dominic Bresser   +9 more
wiley   +1 more source