Results 61 to 70 of about 54,674 (259)

A descriptive case series of hepatotoxicity associated with CFTR modulators and possible relevance of pharmacogenetic polymorphisms in cystic fibrosis patients

British Journal of Clinical Pharmacology, EarlyView.
Cystic fibrosis transmembrane conductance regulator (CFTR) modulators are widely used in patients with cystic fibrosis and significantly improve respiratory function and quality of life. However, their effectiveness may be limited by liver damage, which sometimes leads to treatment discontinuation, and the mechanisms underlying this remain poorly ...
Clara Laffitte Redondo, Venceslas Bourdin, Abd El Kader Ait Tayeb, Sihem Benaboud, Inès Martins, Caroline Joyau, Myriam Benhamida, Isabelle Sermet‐Gaudelus, Clémence Martin, Pierre Régis Burgel, Céline Verstuyft, Laurent Chouchana, Estelle Ayme‐Dietrich   +12 more
wiley   +1 more source

IVA Y DERECHOS DE EMISIÓN: ESPECIAL REFERENCIA A SU UTILIZACIÓN COMO INSTRUMENTO DE FRAUDE [PDF]

Crónica Tributaria, 2010
La ausencia de normativa comunitaria sobre el tratamiento en el IVA de los derechos de emisión ha propiciado que, tras la detección de presuntos supuestos de fraude, diversos Estados miembros se hayan apartado de las Directrices aprobadas por unanimidad
Iñaki Bilbao Estrada, Jesús Rodríguez Márquez   +1 more
doaj  

Towards a Mean‐Field Braginskii Model for Stellarators

Contributions to Plasma Physics, EarlyView.
ABSTRACT Experiments in the stellarator Wendelstein 7‐X indicate that particle drifts have a significant impact on the plasma in the scrape‐off layer. However, drift effects have been absent in the mean‐field transport codes such as EMC3‐Eirene. For this reason, we present the first steps towards a mean‐field model that incorporates drifts. The code is
T. Tork, F. Reimold, D. Bold, B. Shanahan, B. Dudson, A. Stegmeir, P. Manz, The W7‐X Team   +7 more
wiley   +1 more source

The taxes in the agricultural professional activity and the commercialisation of bov i ne meat, dairy products and grains in La Pampa province SEPARAR RESALTAR

Ciencia Veterinaria, 2017
Taxes on the agricultural professional activity and commercialization of beef, dairy products and grains in La Pampa province. As takes provoke a deep impact on taxpayers' contribution, their effects in the veterinary profession as well as in beef, dairy
Adrián Sanchez, Carlos Daniel Saravia, Luis Alejo Balestri   +2 more
doaj  

Diagnostic Usefulness of Cell Block Samples in Fluid Overload‐Associated Large B‐Cell Lymphoma

Diagnostic Cytopathology, EarlyView.
ABSTRACT Fluid overload‐associated B‐cell lymphoma (FO‐LBCL) is a B‐cell neoplasm that presents as serous effusions without detectable tumor masses and Kaposi sarcoma‐associated herpesvirus (KSHV)/human herpesvirus 8 (HHV8) infection. Here, we report a case of an 81‐year‐old female patient with FO‐LBCL (Stage IVA) who presented with pericardial and ...
Hiroyuki Okanishi, Hiroko Kuwabara, Hiroko Nakayama, Mayo Odaka, Kozue Ariga, Isako Kataoka, Mari Tomiuka, Mayumi Uragami, Chihiro Deguchi, Shizuka Ono, Reika Takeda, Yoshitaka Kurisu, Yoshinobu Hirose, Yuuki Kinoshita, Taiji Yokote   +14 more
wiley   +1 more source

Genetic testing among patients evaluated for epilepsy surgery

Epileptic Disorders, EarlyView.
Abstract Objective Genetic testing performed to identify the underlying etiology of epilepsy has become increasingly common and is now being recommended as part of the presurgical evaluation for epilepsy surgery. This study aimed to characterize the types of genetic tests performed in patients evaluated for epilepsy surgery and assess how genetic ...
Anni Saarela, Veera‐Julia Kuronen, Oskari Timonen, Leena Jutila, Katri Silvennoinen, Annemari Kilpeläinen, Jarkko Kirjavainen, Reetta Kälviäinen   +7 more
wiley   +1 more source

High incidence of Y‐chromosome mosaicism in male and female individuals with mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy

Epilepsia, EarlyView.
Abstract Objective Mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) is an underrecognized pediatric cortical lesion associated with somatic X‐linked SLC35A2 variants in approximately 50% of individuals. The genetic etiology in individuals without detectable SLC35A2 mutations remains undefined, which limits
Erica Cecchini, Till Hartlieb, Ahmed Gaballa, Katja Kobow, Mitali Katoch, Paraskevi Chasani, Georgia Vasileiou, Wiebke Hofer, Lea M. Reisch, Manfred Kudernatsch, Christian G. Bien, Roland Coras, Ingmar Blümcke, Lucas Hoffmann   +13 more
wiley   +1 more source

Epileptic arousals: A neglected clinical entity

Epilepsia, EarlyView.
Abstract Objective Epileptic arousals (EAs) are seizures characterized solely by arousal from sleep. EAs are unrecognized in current seizure classifications. Their subtle semiology and inconsistently detectable ictal activity in scalp electroencephalography (EEG) complicate differentiation from physiological arousals (PAs). This study characterizes EAs
Lea Fisel, Nóra Pető, Sotirios Kalousios, Nicolas Zabler, Armin Brandt, Peter C. Reinacher, Dieter Riemann, Mohammad F. Khazali, Andreas Schulze‐Bonhage   +8 more
wiley   +1 more source

Comparison of the 2-Year Results of Photodynamic Therapy with Aflibercept and Aflibercept Monotherapy for Polypoidal Choroidal Vasculopathy

Clinical Ophthalmology, 2023
Tomoko Miyakubo, Ryo Mukai, Hidetaka Matsumoto, Masahiro Morimoto, Maki Takahashi, Kazuki Nagai, Kosuke Nakamura, Junki Hoshino, Hideo Akiyama Department of Ophthalmology, Gunma University, Graduate School of Medicine, Maebashi, Gunma ...
Miyakubo T, Mukai R, Matsumoto H, Morimoto M, Takahashi M, Nagai K, Nakamura K, Hoshino J, Akiyama H   +8 more
doaj  

IVA comunitaria e IVA nazionale

, 2013
L'autore analizza il sistema UE dell'IVA precisamente nei profili dei suoi principi fondamentali, nella disciplina delle prestazioni di servizi, nel sistema del rimborso dell'imposta negli scambi sovranazionali, nelle frodi comunitarie. Si conclude sottolineando le criticità attuali dell'IVA e illustrando le possibili evoluzioni tenuto conto che la ...
openaire   +1 more source