Results 101 to 110 of about 64,202 (309)
ABSTRACT Objective Determine the effect of oral macrocyclic lactone heartworm‐preventative medications on retinal function and chromatic pupillary light reflex (cPLR) in healthy dogs. Animals Studied Cross‐sectional retrospective: 60 dogs (n = 33 females) with heartworm medication administration status and electroretinogram (ERG) data available ...
Ryan G. Hopper+6 more
wiley +1 more source
Efficacy and Safety of Ivermectin for Treatment and prophylaxis of COVID-19 Pandemic
Background: Up-to-date, there is no recognized effective treatment or vaccine for the treatment of COVID-19 that emphasize urgency around distinctive effective therapies.
A. Elgazzar+5 more
semanticscholar +1 more source
Soil-transmitted helminth infections [PDF]
More than a quarter of the world's population is at risk of infection with the soil-transmitted helminths Ascaris lumbricoides, hookworm (Ancylostoma duodenale and Necator americanus), Trichuris trichiura, and Strongyloides stercoralis. Infected children
Addiss, David G.+3 more
core +1 more source
Appraising the visibility, relevance and impacts of clinical pharmacology
Aims Clinical pharmacology (CP) used to be a strong medical and scientific field, but during the last three decades it seems to have lost some of its appeal. We reviewed the visibility, relevance and impact of CP and clinical pharmacologists across the globe and suggest ways to strengthen the discipline to address future pharmacotherapeutic challenges.
Serge Cremers+5 more
wiley +1 more source
Genetic selection of low fertile Onchocerca volvulus by ivermectin treatment. [PDF]
BACKGROUND: Onchocerca volvulus is the causative agent of onchocerciasis, or "river blindness". Ivermectin has been used for mass treatment of onchocerciasis for up to 18 years, and recently there have been reports of poor parasitological responses to ...
Catherine Bourguinat+6 more
doaj +1 more source
Abstract Metabotropic glutamate receptor 5 (mGlu5) is implicated in various neurodegenerative disorders, making it an attractive drug target. Although several ligand‐bound crystal structures of mGlu5 exist, their apo‐state crystal structure remains unknown.
Yasushi Kondo+15 more
wiley +1 more source
Lack of efficacy of standard doses of ivermectin in severe COVID-19 patients.
Ivermectin has recently shown efficacy against SARS-CoV-2 in-vitro. We retrospectively reviewed severe COVID-19 patients receiving standard doses of ivermectin and we compared clinical and microbiological outcomes with a similar group of patients not ...
Daniel Camprubí+8 more
doaj +1 more source
Contrasting sensitivities to toxicants of the freshwater amphipods Gammarus pulex and G. fossarum [PDF]
Amphipods are an important component of freshwater ecosystems. They are very often used in ecotoxicology, particularly the freshwater amphipod Gammarus pulex.
Alonso, A.+2 more
core +2 more sources
Conformational variability of the glycine receptor M2 domain in response to activation by different agonists [PDF]
Models describing the structural changes mediating cys-loop receptor activation generally give little attention to the possibility that different agonists may promote activation via distinct M2 pore-lining domain structural rearrangements.
Akabas+30 more
core +3 more sources
A new polymeric nanoparticle formulation containing aminophenoxazinone DiS‐NH2 (2,2′‐disulfanediyldianiline) is proposed as a post‐emergence and contact bioherbicide for weed management in durum wheat. Abstract BACKGROUND Weed‐resistance phenomena have increased dramatically in recent years. Bioherbicides can offer a sustainable alternative to chemical
Aurelio Scavo+7 more
wiley +1 more source