Results 101 to 110 of about 67,505 (283)

My Journey of Formulating a Patent for Topical/Spray Ivermectin Against COVID [PDF]

, 2021
Craig G. Burkhart
openalex   +1 more source

The exposomal imprint on rosacea: More than skin deep

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Rosacea reflects systemic and environmental interactions, not just a skin disorder. Key factors include environmental triggers, genetic and microbiome influences, diagnostic gaps in skin of colour and social determinants. Advances in multi‐omics and exposome integration highlight pathways towards precision medicine, prevention and equitable, patient ...
Katerina Grafanaki, Daniella Bakoli Sgourou, Alexandros Maniatis, Efstathia Pasmatzi   +3 more
wiley   +1 more source

Functional characterization of ivermectin binding sites in α1β2γ2L GABA(A) receptors

Frontiers in Molecular Neuroscience, 2015
GABAA receptors (GABAARs) are the major inhibitory neurotransmitter receptors in the brain and are therapeutic targets for many indications including sedation, anesthesia and anxiolysis.
Argel eEstrada, Joe eLynch
doaj   +1 more source

Poultry red mite eradication potential of ivermectin and allicin combination treatment

Veterinary Medicine and Science, 2023
Background Existing treatments against poultry red mite (PRM; Dermanyssus gallinae) infestation have reduced efficacy or exhibit hazardous effects on chickens.
JeongWoo Kang, HyunYoung Chae, Md Akil Hossain   +2 more
doaj   +1 more source

P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes [PDF]

, 2008
ATP plays an important role in signal transduction between neuronal and glial circuits and within glial networks. Here we describe currents activated by ATP in astrocytes acutely isolated from cortical brain slices by non-enzymatic mechanical ...
Kirchhoff, Frank, Lalo, Ulyana, North, R. Alan, Pankratov, Yuriy, Rossner, Moritz J., Verkhratskiĭ, A. N. (Alekseĭ Nestorovich), Wichert, Sven P.   +6 more
core   +1 more source

Efficacy and Safety of Ivermectin and Hydroxychloroquine in Patients with Severe COVID-19: A Randomized Controlled Trial

medRxiv, 2021
Background In the search for active drugs against COVID19, the indications of many have been redirected. Ivermectin and Hydroxychloroquine are drugs that inhibit viral replication in vitro and that have been used in several medical centers.
Jose Lenin Beltran Gonzalez, Mario González Gámez, Emanuel Antonio Mendoza Enciso, Ramiro Josue Esparza Maldonado, Daniel Hernández Palacios, Samuel Dueñas Campos, Itzel Ovalle Robles, M. J. Macías Guzmán, A. L. García Díaz, C. M. Gutiérrez Peña, Lucila Martinez Medina, V. A. Monroy Colin, José Manuel Arreola Guerra   +12 more
semanticscholar   +1 more source

The Prevalence of Scabies, Skin Infection and Rheumatic Heart Disease in a Cross‐Sectional Study of Tongan Primary School Children

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Background Scabies is a common health issue in the Pacific and may contribute to rheumatic heart disease (RHD). This study assessed the prevalence of scabies and other skin conditions among Tongan schoolchildren and examined the association between these conditions and RHD.
Simon Thornley, Toakase Fakakovikaetau, Mele Tilema Cama, Mele ‘Atuekaho Manu, Kalolaine Tahitua, Shunsuke Moritsuka, Richard J. Johnson, Viliami Puloka, Losana Vuki, Joseph Takai, Jacqui Williamson, Saptorshi Gupta, Arthur J. Morris, Gerhard Sundborn   +13 more
wiley   +1 more source

Structural model, functional modulation by ivermectin and tissue localization of Haemonchus contortus P-glycoprotein-13

International Journal for Parasitology: Drugs and Drug Resistance, 2018
Haemonchus contortus, one of the most economically important parasites of small ruminants, has become resistant to the anthelmintic ivermectin. Deciphering the role of P-glycoproteins in ivermectin resistance is desirable for understanding and overcoming
Marion David, Chantal Lebrun, Thomas Duguet, Franck Talmont, Robin Beech, Stéphane Orlowski, François André, Roger K. Prichard, Anne Lespine   +8 more
doaj   +1 more source

The macrofilaricidal efficacy of repeated doses of ivermectin for the treatment of river blindness [PDF]

, 2017
Background: Mass drug administration (MDA) with ivermectin is the cornerstone of efforts to eliminate human onchocerciasis by 2020 or 2025. The feasibility of elimination crucially depends on the effects of multiple ivermectin doses on Onchocerca ...
Basáñez, Maria-Gloria, Boussinesq, Michel, Chesnais, Cédric, Chippaux, Jean-Philippe, Ernould, Jean-Christophe, Fang, Hanwei, Garcia, André, Gardon, J., Kamgno, Joseph, Pion, Sébastien, Ranque, Stephane, Tchatchueng-Mbougua, Jules Brice, Walker, Martin   +12 more
core   +3 more sources

Comparison of Human and Canine P‐Glycoprotein Substrates at R, P, and H Binding Sites

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT P‐glycoprotein (P‐gp) greatly impacts substrate drug disposition, so much so that regulatory agencies recommend ascertaining the P‐gp status of active pharmaceutical ingredients (APIs) intended for human use. Arguably, the P‐gp status of drugs intended for canine patients is equally, if not more, important.
Neal S. Burke, Katrina L. Mealey
wiley   +1 more source