Results 101 to 110 of about 64,202 (309)

Effects of Oral Macrocyclic Lactone Heartworm Preventatives on Retinal Function and Chromatic Pupillary Light Reflex in Healthy Companion Dogs

open access: yesVeterinary Ophthalmology, EarlyView.
ABSTRACT Objective Determine the effect of oral macrocyclic lactone heartworm‐preventative medications on retinal function and chromatic pupillary light reflex (cPLR) in healthy dogs. Animals Studied Cross‐sectional retrospective: 60 dogs (n = 33 females) with heartworm medication administration status and electroretinogram (ERG) data available ...
Ryan G. Hopper   +6 more
wiley   +1 more source

Efficacy and Safety of Ivermectin for Treatment and prophylaxis of COVID-19 Pandemic

open access: yes, 2020
Background: Up-to-date, there is no recognized effective treatment or vaccine for the treatment of COVID-19 that emphasize urgency around distinctive effective therapies.
A. Elgazzar   +5 more
semanticscholar   +1 more source

Soil-transmitted helminth infections [PDF]

open access: yes, 2018
More than a quarter of the world's population is at risk of infection with the soil-transmitted helminths Ascaris lumbricoides, hookworm (Ancylostoma duodenale and Necator americanus), Trichuris trichiura, and Strongyloides stercoralis. Infected children
Addiss, David G.   +3 more
core   +1 more source

Appraising the visibility, relevance and impacts of clinical pharmacology

open access: yesBritish Journal of Clinical Pharmacology, Volume 91, Issue 7, Page 1884-1898, July 2025.
Aims Clinical pharmacology (CP) used to be a strong medical and scientific field, but during the last three decades it seems to have lost some of its appeal. We reviewed the visibility, relevance and impact of CP and clinical pharmacologists across the globe and suggest ways to strengthen the discipline to address future pharmacotherapeutic challenges.
Serge Cremers   +5 more
wiley   +1 more source

Genetic selection of low fertile Onchocerca volvulus by ivermectin treatment. [PDF]

open access: yesPLoS Neglected Tropical Diseases, 2007
BACKGROUND: Onchocerca volvulus is the causative agent of onchocerciasis, or "river blindness". Ivermectin has been used for mass treatment of onchocerciasis for up to 18 years, and recently there have been reports of poor parasitological responses to ...
Catherine Bourguinat   +6 more
doaj   +1 more source

Apo‐state structure of the metabotropic glutamate receptor 5 transmembrane domain obtained using a photoswitchable ligand

open access: yesProtein Science, Volume 34, Issue 7, July 2025.
Abstract Metabotropic glutamate receptor 5 (mGlu5) is implicated in various neurodegenerative disorders, making it an attractive drug target. Although several ligand‐bound crystal structures of mGlu5 exist, their apo‐state crystal structure remains unknown.
Yasushi Kondo   +15 more
wiley   +1 more source

Lack of efficacy of standard doses of ivermectin in severe COVID-19 patients.

open access: yesPLoS ONE, 2020
Ivermectin has recently shown efficacy against SARS-CoV-2 in-vitro. We retrospectively reviewed severe COVID-19 patients receiving standard doses of ivermectin and we compared clinical and microbiological outcomes with a similar group of patients not ...
Daniel Camprubí   +8 more
doaj   +1 more source

Contrasting sensitivities to toxicants of the freshwater amphipods Gammarus pulex and G. fossarum [PDF]

open access: yes
Amphipods are an important component of freshwater ecosystems. They are very often used in ecotoxicology, particularly the freshwater amphipod Gammarus pulex.
Alonso, A.   +2 more
core   +2 more sources

Conformational variability of the glycine receptor M2 domain in response to activation by different agonists [PDF]

open access: yes, 2007
Models describing the structural changes mediating cys-loop receptor activation generally give little attention to the possibility that different agonists may promote activation via distinct M2 pore-lining domain structural rearrangements.
Akabas   +30 more
core   +3 more sources

Field efficacy of a bioherbicide mimic (DiS‐NH2) in a nanoparticle formulation for weed control in durum wheat

open access: yesPest Management Science, Volume 81, Issue 7, Page 3796-3810, July 2025.
A new polymeric nanoparticle formulation containing aminophenoxazinone DiS‐NH2 (2,2′‐disulfanediyldianiline) is proposed as a post‐emergence and contact bioherbicide for weed management in durum wheat. Abstract BACKGROUND Weed‐resistance phenomena have increased dramatically in recent years. Bioherbicides can offer a sustainable alternative to chemical
Aurelio Scavo   +7 more
wiley   +1 more source

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