Results 101 to 110 of about 66,840 (318)

A five-day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness

International Journal of Infectious Diseases, 2021
Ivermectin, a US Food and Drug Administration-approved anti-parasitic agent, was found to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in vitro.
Sabeena Ahmed, Mohammad Mahbubul Karim, Allen G. Ross, Mohammad Sharif Hossain, John D. Clemens, Mariya Kibtiya Sumiya, Ching Swe Phru, Mustafizur Rahman, Khalequ Zaman, Jyoti Somani, Rubina Yasmin, Mohammad Abul Hasnat, Ahmedul Kabir, Asma Binte Aziz, Wasif Ali Khan   +14 more
doaj   +1 more source

The therapeutic efficacy and macrofilaricidal activity of doxycycline for the treatment of river blindness [PDF]

, 2014
Background. Onchocerca volvulus and lymphatic filariae, causing river blindness and elephantiasis, depend on endosymbiotic Wolbachia bacteria for growth, development, fertility, and survival.
Achim Hoerauf, Agwuh, Basáñez, Basáñez, Bosshardt, Cattamanchi, Chib, Churcher, de Andrade, Debrah, Duke, Duke, Gardon, Gelman, Hoerauf, Hoerauf, Hoerauf, Hoerauf, Hoerauf, Hoerauf, Hoerauf, Mand, Mark J. Taylor, Martin Walker, María-Gloria Basáñez, Norton, Osei-Atweneboana, Plaisier, Plaisier, Roberts, Sabine Specht, Specht, Tamarozzi, Taylor, Taylor, Taylor, Taylor, Taylor, Thomas S. Churcher, van Rie, Wanji, Wearing, World Health Organization, Xia   +43 more
core   +2 more sources

P2X7 receptor antagonism suppresses epileptiform‐like activity in an inflammation‐primed human iPSC‐derived neuron model of drug‐resistant epilepsy

British Journal of Pharmacology, EarlyView.
Background and Purpose Neuroinflammation is increasingly recognised to contribute to drug‐resistant epilepsy. Activation of ATP‐gated P2X7 receptors has emerged as an important upstream mechanism, and increased P2X7 receptor expression is present in the seizure focus in rodent models and patients. Pharmacological antagonists of P2X7 receptors attenuate
Jaideep Kesavan, Yitao Wang, Klaus Dinkel, Michael Hamacher, Jochen H. M. Prehn, David C. Henshall, Tobias Engel   +6 more
wiley   +1 more source

Functional characterization of ivermectin binding sites in α1β2γ2L GABA(A) receptors

Frontiers in Molecular Neuroscience, 2015
GABAA receptors (GABAARs) are the major inhibitory neurotransmitter receptors in the brain and are therapeutic targets for many indications including sedation, anesthesia and anxiolysis.
Argel eEstrada, Joe eLynch
doaj   +1 more source

Dosing pole recommendations for lymphatic filariasis elimination: A height-weight quantile regression modeling approach [PDF]

, 2019
BACKGROUND: The World Health Organization (WHO) currently recommends height or age-based dosing as alternatives to weight-based dosing for mass drug administration lymphatic filariasis (LF) elimination programs.
Dubray, Christine, Fischer, Peter U, Goss, Charles W, Hardy, Myra, Jambulingam, Purushothaman, King, Christopher L, Laman, Moses, Lemoine, Jean Frantz, O\u27Brian, Katiuscia, Robinson, Leanne J, Samuela, Josaia, Schechtman, Kenneth B, Subramanian, Swaminathan, Supali, Taniawati, Weil, Gary J   +14 more
core   +2 more sources

Ivermectin as a potential treatment for mild to moderate COVID-19: A double blind randomized placebo-controlled trial

medRxiv, 2021
Objective: Ivermectin has been suggested as a treatment for COVID-19.This randomised control trial was conducted to test the efficacy of Ivermectin in the treatment of mild and moderate COVID-19.
R. Kirti, R. Roy, C. Pattadar, R. Raj, N. Agarwal, B. Biswas, P. Manjhi, D. Rai, S. Shyama, A. Kumar, A. Sarfaraz   +10 more
semanticscholar   +1 more source

Rainfall shapes the physiological condition, but not the body size, of an introduced dung beetle in Brazilian pastures

Ecological Entomology, EarlyView.
Understanding rainfall‐driven physiological shifts in dung beetles is crucial to predict how climate change may affect the fitness and persistence of key insect species in tropical pastures. We compared body size, dry, lipid and muscle masses of Digitonthophagus gazella collected during dry and rainy seasons in Brazilian pastures to assess the effects ...
Cleilsom M. Cristaldo, Renato Portela Salomão, Pedro Lucas Moreira de Oliveira, Alfredo Raúl Abot, César Murilo de Albuquerque Correa   +4 more
wiley   +1 more source

Presence of the ABCB1 (MDR1) deletion mutation causing ivermectin hypersensitivity in certain dog breeds in Belgium [PDF]

, 2009
Hypersensitivity to ivermectin and certain other drugs in Collies and related breeds is caused by a 4-base pair deletion mutation in the ABCB1 gene, better known as the MDR1 gene, encoding P-glycoprotein.
Daminet, Sylvie, Erkens, Tim, Gommeren, Kris, Lampo, Evelyne, Peelman, Luc, Rogiers, Carolien, Van den Broeke, Alice, Van Poucke, Mario, Van Zeveren, Alex, Vander Donckt, Dominique   +9 more
core   +2 more sources

Importance of a Rapid and Accurate Diagnosis in Strongyloides Stercoralis and Human T-Lymphotropic Virus 1 Co-infection: A Case Report and Review of the Literature [PDF]

, 2017
Strongyloides (S.) stercoralis and Human T-Lymphotropic Virus 1 (HTLV-1) share some endemic regions such as Japan, Jamaica, and South America and are mostly diagnosed elsewhere in immigrants from endemic areas.
Avagnina, Alejandra, Berini, Carolina Andrea, Biglione, Mirna Marcela, Juarez, María, Quintero, Olga, Repetto, Silvia, Sorda, Juan, Waldbaum, Carlos   +7 more
core   +2 more sources

Enhanced detection of equine strongyles: Insights from morphological and nemabiome metabarcoding approaches in northern Iran

Equine Veterinary Journal, EarlyView.
Abstract Background Strongyles pose significant health concerns for equids globally. Strongyles, comprising over 60 species, can lead to severe morbidity and mortality, with Strongylus vulgaris posing higher risks due to its migratory behaviour. Routine diagnostic methods, such as faecal egg counts, lack species‐level resolution, while traditional ...
Sina Mohtasebi, Sangwook Ahn, Mahan Karimi, Mohammad Saberi, John S. Gilleard, Jocelyn Poissant   +5 more
wiley   +1 more source