Results 61 to 70 of about 22,686,556 (351)

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Temperature effect on fatigue crack propagation in short-carbon-fiber reinforced PPS

Nihon Kikai Gakkai ronbunshu, 2017
The effect of test temperature on the fatigue crack propagation behavior was studied with center-notched specimens of PPS (polyphenylene sulfide) reinforced with 30 wt% short carbon fibers.
Keisuke TANAKA, Kazuya OHARADA, Yuya HASEGAWA, Kenichi SHIMIZU   +3 more
doaj   +1 more source

Validation of a finite element model for fracture mechanics specimens [PDF]

, 2012
Single parameter formulations have shown to be insufficient to describe constraint effects in fracture mechanics specimens. This has lead researchers to a two parameter approach like the J-Q theory. In order to investigate constraint effects, the authors
Cauwelier, Matthias, De Waele, Wim, Hertelé, Stijn, Maelfait, Jens, Van Minnebruggen, Koen, Verstraete, Matthias   +5 more
core  

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Nonlinear Fatigue Crack Growth Simulations using J-integral Decomposition and XFEM

, 2017
In the present work, nonlinear fatigue crack growth analysis of an inclined edge crack is performed by extended finite element method (XFEM) [1] . The material behavior is assumed to be nonlinear, which is modelled by Ramberg-Osgood model and von-Mises ...
Manish Kumar, A. S. Bhuwal, I. Singh, B. Mishra, S. Ahmad, A. Rao, V. Kumar   +6 more
semanticscholar   +1 more source

A simulation method for fatigue-driven delamination in layered structures involving non-negligible fracture process zones and arbitrarily shaped crack fronts

, 2019
Most of the existing methods for fatigue-driven delamination are limited to two-dimensional (2D) applications or their predictive capabilities have not been validated in three-dimensional (3D) problems.
Bak, Brian L. V., Carreras, Laura, de la Escalera, Federico M., Essa, Yasser, Lindgaard, Esben, Renart, Jordi, Turon, Albert   +6 more
core   +1 more source

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

A disk-shaped domain integral method for the computation of stress intensity factors using tetrahedral meshes [PDF]

, 2015
A novel domain integral approach is introduced for the accurate computation of pointwise J-integral and stress intensity factors (SIFs) of 3D planar cracks using tetrahedral elements. This method is efficient and easy to implement, and does not require a
Nejati, M, Paluszny, A, Zimmerman, RW
core   +1 more source