Results 101 to 110 of about 392,474 (265)

Hydrogen Embrittlement Evaluation of Micro Alloyed Steels by Means of J-Integral Curve. [PDF]

open access: yesMaterials (Basel), 2019
Cabrini M   +5 more
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

A Simple Method for Estimation of J-Integral and Modified J-Integral

open access: yesTRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series A, 1981
Kiyotsugu OHJI, Keiji OGURA, Shiro KUBO
openaire   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

CONSTRAINT EFFECT ANALYSIS OF THE SEMI-ELLIPTICAL SURFACE CRACK FOR A REACTOR VESSEL SUBJECTED TO PRESSURIZED

open access: yesJixie qiangdu, 2017
The specimen is a reactor pressure vessel with a semi-elliptical surface crack with axial orientation and its 3D finite element numerical modeling is built. Based on J-A2 two parameters method,analysis is performed by considering constraint effect,at T =
WANG ZhongXian, GUO HuaJing
doaj  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Insights on the J‐integral expression of pure shear carbon black filled natural rubber specimen and predicting the crack growth rate using finite element method

open access: yesSPE Polymers
The J‐integral approach manifests itself in an efficient way to determine the crack growth and failure mechanism of tread and sidewall compounds used in tyres.
Anandarup Bhattacharyya   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

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