Results 41 to 50 of about 958,890 (240)

Macrophage-derived upd3 Cytokine causes impaired glucose homeostasis and reduced lifespan in drosophila fed a lipid-rich diet [PDF]

, 2014
Long-term consumption of fatty foods is associated with obesity, macrophage activation and inflammation, metabolic imbalance, and a reduced lifespan. We took advantage of Drosophila genetics to investigate the role of macrophages and the pathway(s) that ...
Dionne, MS, Geissmann, F, Kierdorf, K, Pouchelon, CA, Vivancos, V, Woodcock, KJ   +5 more
core   +1 more source

Long non-coding RNAs and JAK/STAT signaling pathway regulation in colorectal cancer development

Frontiers in Genetics, 2023
Colorectal cancer (CRC) is one of the main fatal cancers. Cell signaling such as Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling substantially influences the process of gene expression and cell growth.
A. Ghasemian, H. Omear, Y. Mansoori, Pardis Mansouri, X. Deng, Farzaneh Darbeheshti, E. Zarenezhad, M. Kohansal, Babak Pezeshki, Zhangling Wang, Hailin Tang   +10 more
semanticscholar   +1 more source

The use of thermodynamic modeling to examine alkali recirculation in the iron blast furnace [PDF]

, 2012
It is widely recognized that alkali metals, such as, potassium and sodium can cause operational problems in the iron blast furnace. These elements can influence properties, such as, the softening and melting of ores, formation of scaffolds, coke ...
Hayes, Peter, Jak, Evgueni
core   +1 more source

Paleolityczny sen (jak daleko stąd, jak blisko)

, 2023
The present essay is an attempt to answer the fundamental question: whether communication with the sphere of the sacred, as experienced in old cultures, is still possible in the present-day period of the proliferation of ‘religion of secularism’ (Roberto Calasso).
openaire   +2 more sources

Inhibitors of CK2 Kinase for the Treatment of Gliomas and Other Brain Tumors [PDF]

Acta Poloniae Pharmaceutica
Protein kinase CK2 has become a target of experimental antiglioma therapies as laboratory data are almost uniformly favorable and the number of synthetized CK2 inhibitors is rapidly growing.
Emanuela B. Pucko, Robert P. Ostrowski
doaj   +1 more source

JAK/STAT signaling in diabetic kidney disease

Frontiers in Cell and Developmental Biology, 2023
Diabetic kidney disease (DKD) is the most important microvascular complication of diabetes and the leading cause of end-stage renal disease (ESRD) worldwide.
Yingjun Liu, Wenkuan Wang, Jintao Zhang, Shuowei Gao, Tingting Xu, Yonghui Yin   +5 more
semanticscholar   +1 more source

Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma

Drug Design, Development and Therapy, 2022
Magnus Nilsson,1 Magdalena Rhedin,2 Ramon Hendrickx,3 Susanne Berglund,1 Antonio Piras,2 Parmis Blomgran,2 Anders Cavallin,2 Mia Collins,2 Göran Dahl,4 Bilel Dekkak,5 Therese Ericsson,3 Niklas Hagberg,6 Ann Aurell Holmberg,3 Agnes Leffler,2 Anders J ...
Nilsson M, Rhedin M, Hendrickx R, Berglund S, Piras A, Blomgran P, Cavallin A, Collins M, Dahl G, Dekkak B, Ericsson T, Hagberg N, Holmberg AA, Leffler A, Lundqvist AJ, Markou T, Pinkerton J, Rönnblom L, Siu S, Taylor V, Wennberg T, Zervas D, Laurence ADJ, Mitra S, Belvisi MG, Birrell M, Borde A   +26 more
doaj  

Tacy jak my [PDF]

, 2012
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Grzegorzewska, Alina
core   +2 more sources

Narrative-based computational modelling of the Gp130/JAK/STAT signalling pathway. [PDF]

, 2008
BACKGROUND: Appropriately formulated quantitative computational models can support researchers in understanding the dynamic behaviour of biological pathways and support hypothesis formulation and selection by "in silico" experimentation.
A Herrmann, A Mahdavi, A Regev, A Regev, A Singh, A Verma, AD Sharrocks, Anna Dudka, B Alberts, C Priami, C Priami, Corrado Priami, D Gillespie, F Ciocchetta, I Lödige, I Swameye, J Bravo, J Fisher, J Heath, J ten Hoeve, John K Heath, K Rakesh, L Dematté, L Dematté, L Klampfer, M Calder, M Kwiatkowska, Maria Luisa Guerriero, ML Guerriero, ML Guerriero, ML Guerriero, N Underhill-Day, NC Reich, Nicholas Underhill-Day, P Heinrich, S Bhattacharya, T Yamamoto, WS Alexander   +37 more
core   +7 more sources

Role of JAK/STAT in Interstitial Lung Diseases; Molecular and Cellular Mechanisms

International Journal of Molecular Sciences, 2021
Interstitial lung diseases (ILDs) comprise different fibrotic lung disorders characterized by cellular proliferation, interstitial inflammation, and fibrosis.
P. Montero, J. Milara, I. Roger, J. Cortijo   +3 more
semanticscholar   +1 more source