Results 61 to 70 of about 958,890 (240)
Oncogene, 2005 A somatic mutation that leads to activation of the JAK2 tyrosine kinase has recently been identified as a recurrent genetic abnormality in several different myeloproliferative disorders. A translocation generating the constitutively activated fusion protein PCM1-JAK2 has also been recently found in atypical chronic myelogenous leukemia and acute ...
openaire +2 more sources
JAK/STAT Signaling and Cervical Cancer: From the Cell Surface to the Nucleus
Genes, 2023 The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway constitutes a rapid signaling module from the cell surface to the nucleus, and activates different cellular responses, such as proliferation, survival ...
Arturo Valle-Mendiola +2 more
semanticscholar +1 more source
Interleukin‐6 role in head and neck squamous cell carcinoma progression
World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 2, Issue 2, Page 90-97, June 2016., 2016 Abstract Interleukin‐6 (IL‐6) is a pleiotropic cytokine which plays an important role in a number of cellular processes including proliferation, survival, differentiation, migration and invasion. IL‐6 mediates its downstream effects by activating a number of signaling cascades including JAK/STAT, PI3K/AKT and MAPK pathways.
Moaz M. Choudhary +3 more
wiley +1 more source
Clinical, Cosmetic and Investigational Dermatology, 2023 Qiannan Xu, Nan Xu Department of Dermatology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of ChinaCorrespondence: Nan Xu, Tel +86 38804518, Email xnhrb@sina.comAbstract: Dermatomyositis is a rare inflammatory
Xu Q, Xu N
doaj
Frontiers in Pharmacology, 2022 JAK/STAT signaling pathway is one of the important regulatory signaling cascades for the myriad of cellular processes initiated by various types of ligands such as growth factors, hormones, and cytokines. The physiological processes regulated by JAK/STAT
B. Rah +15 more
semanticscholar +1 more source
Romanian Journal of Internal MedicineThis study aimed to assess cardiac function using the Myocardial Performance Index (MPI) in spondyloarthritis (SpA) patients.
Alvianto Steven +6 more
doaj +1 more source
Application of activity - based costing in companies in Poland [PDF]
, 2010 Findings of the research have both practical and theoretical implications. First, from the practical point of view, future implementers of ABC systems should be aware of factors actually influencing ABC implementation as well as problems which can be ...
Wnuk-Pel, Tomasz
core +2 more sources
Advanced Science, Volume 12, Issue 38, October 13, 2025.This study identifies α‐Hederin as a potent dual JAK1/JAK2 inhibitor that blocks STAT3 activation in ovarian cancer. By disrupting STAT3‐driven transcriptional programs, α‐Hederin suppresses tumor proliferation, invasion, and EMT, while enhancing cisplatin efficacy and overcoming chemoresistance.
Jiayu Wang +9 more
wiley +1 more source
Keyif haritasındaki Park Otel [PDF]
, 1988 Taha Toros Arşivi, Dosya No: 115-Otellerİstanbul Kalkınma Ajansı (TR10/14/YEN/0033) İstanbul Development Agency (TR10/14/YEN ...
Deleon, Jak
core
Emergent properties hidden in plane view: Strong electronic correlations at oxide interfaces
, 2014 Finding new collective electronic states in materials is one of the fundamental goals of condensed matter physics. Atomic-scale superlattices formed from transition metal oxides are a particularly appealing hunting ground for new physics.
Chakhalian, Jak +4 more
core +1 more source