JAK inhibitors for the treatment of VEXAS syndrome [PDF]
, 2023 Sara Bindoli +4 more
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Communications Biology, 2022 RNA sequencing of MEK inhibitor (selumetinib)-treated tumors reveals an upregulation of the JAK/STAT3 pathway, with combinatorial therapeutic strategies of JAK/STAT3 inhibitors and selumetinib investigated for the SHH subgroup of medulloblastoma.
Jamie Zagozewski +18 more
doaj +1 more source
Signal transducer and activator of transcription-1 localizes to the mitochondria and modulates mitophagy [PDF]
, 2013 The signal transducer and activator of transcription (STAT) proteins are latent transcription factors that have been shown to be involved in cell proliferation, development, apoptosis, and autophagy. STAT proteins undergo activation by phosphorylation at
Ambrosio G +9 more
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Relieving severe itching caused by scabies with tofacitinib: A case report
Clinical Case Reports, 2023 Key Clinical Message In this paper, we present a case of relieving severe itching caused by scabies with tofacitinib. We show that the tofacitinib can quickly alleviate the itching caused by scabies, and this case may indicate a new option for ...
Zhenze Yu +3 more
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Targeting of Prosurvival Pathways as Therapeutic Approaches against Primary Effusion Lymphomas: Past, Present, and Future [PDF]
, 2015 Constitutively activated prosurvival pathways render cancer cells addicted to their effects. Consequently they turn out to be the Achilles’ heels whose inhibition can be exploited in anticancer therapy.
CIRONE, Mara +6 more
core +4 more sources
Efficacy of JAK Inhibitors versus DMARDs in the Treatment of Polymyalgia Rheumatica in China
International Journal of General Medicine, 2023 Juanfang Gu,1,2 Mingfeng Yang,1,2 Bin Zhang,1,2 Hongzhi Wang1,2 1Department of Rheumatology and Immunology, The Affiliated Hospital of Jiaxing University (The First Hospital of Jiaxing), Jiaxing, Zhejiang, 314300, People’s Republic of China; 2Jiaxing Key
Gu J, Yang M, Zhang B, Wang H
doaj
Essential gene pathways for glioblastoma stem cells: clinical implications for prevention of tumor recurrence. [PDF]
, 2011 Glioblastoma (World Health Organization/WHO grade IV) is the most common and most aggressive adult glial tumor. Patients with glioblastoma, despite being treated with gross total resection and post-operative radiation/chemotherapy, will almost always ...
Choe, Jinny +6 more
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How and why systemic inflammation worsens quality of life in patients with advanced cancer [PDF]
, 2017 Introduction: The presence of an innate host systemic inflammatory response has been reported to be a negative prognostic factor in a wide group of solid tumour types in both the operable and advanced setting, both local and distant.
Dolan, Ross D. +4 more
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Immunological MedicineScleritis is often associated with systemic inflammatory diseases, and a subset of patients remains refractory to conventional therapies, including corticosteroids, immunosuppressants, and tumor necrosis factor inhibitors (TNFi). Janus kinase inhibitors (
Kodai Yuge +5 more
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AB0383 COMPARISON OF EFFICACY AND SAFETY IN JAK INHIBITOR DUE TO A DIFFERENCE OF SELECTIVITY – TOFACITINIB vs. BARICITINIB – [PDF]
, 2022 Ichiro Yoshii +2 more
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