Results 61 to 70 of about 89,537 (296)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
JAK Inhibitors and Oxidative Stress Control [PDF]
Frontiers in Immunology, 2019 Primary Sjögren's syndrome (SjS) is a complex autoimmune epithelitis, with few treatment options, but the use of Janus kinase (JAK) inhibitors is promising because suppression of the JAK/signal transducer and activator of transcription (STAT) pathway improves sicca manifestations.
Amandine Charras +11 more
openaire +4 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
, 2013 M-CSF differentiated macrophages derived from unselected human CD16+/− monocytes were untreated or classically activated with IFNγ. (A) Phospho and total STAT-1 were measured after 45 minutes of IFNγ with and without JAK-2 inhibitor, 10 or 20 µM ABSPI as
Jason L. Johnson (312727) +4 more
core +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
JAK-STAT6 inhibitors decrease IL-13-induced eotaxin-3 expression in esophageal fibroblasts.
, 2016 IL-13-induced (a) STAT6 phosphorylation, (b) eotaxin-3 mRNA, and (c) eotaxin-3 protein expression are decreased in esophageal fibroblasts, following treatment with JAK-STAT6 inhibitors (AS1517499 and leflunomide).
Xi Zhang (83736) +9 more
core +1 more source
Developing a JAK Inhibitor for Targeted Local Delivery: Ruxolitinib Cream
, 2021 Named after the two-faced Roman god of doorways, Janus kinases (JAKs) represent a class of tyrosine kinases. The JAK signaling pathway is pivotal for the downstream signaling of inflammatory cytokines, including interleukins, interferons, and multiple ...
Paul Smith +9 more
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
JAK-STAT6 inhibitors decrease IL-13-induced eotaxin-3 expression in esophageal epithelial cells.
, 2016 IL-13-induced (a) STAT6 phosphorylation, (b) eotaxin-3 mRNA, and (c) eotaxin-3 protein expression are decreased in esophageal epithelial cells, following treatment with JAK-STAT6 inhibitors (AS1517499 and leflunomide).
Xi Zhang (83736) +9 more
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source