Results 141 to 150 of about 126,141 (353)

Non-Invasive Assessment of Micro- and Macrovascular Function after Initiation of JAK Inhibitors in Patients with Rheumatoid Arthritis

Diagnostics
Background: Janus kinase (JAK) inhibitors constitute a novel class of oral biologic disease-modifying antirheumatic drugs for patients with rheumatoid arthritis (RA).
Panagiota Anyfanti, Elena Angeloudi, Athanasia Dara, Eleni Pagkopoulou, Georgia-Savina Moysidou, Kleopatra Deuteraiou, Maria Boutel, Eleni Bekiari, Michael Doumas, George D. Kitas, Theodoros Dimitroulas   +10 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Presenting JAK inhibitor safety information to dermatology patients

JEADV Clinical Practice
Janus Kinase (JAK) inhibitors are treatment options for dermatologic conditions such as atopic dermatitis, psoriasis, vitiligo, and alopecia areata. Guidance on how to counsel patients on these novel treatments is limited.
Anthony J. Teixeira, Jessica Q. Duong, Shirley P. Parraga, Steven R. Feldman   +3 more
doaj   +1 more source

Janus kinase and signal transducer and activator of transcription inhibitors in type 1 diabetes and immune checkpoint–related diabetes: current status and future perspectives

Frontiers in Immunology
Type 1 diabetes (T1D) is an autoimmune-mediated disorder that leads to the destruction of pancreatic beta-cells, insulin deficiency, and chronic hyperglycemia. It is one of the most common childhood endocrine disorders.
Bowei Su, Bowei Su, Zhi-Lin Luan, Haixia Liu, Jaakko Tuomilehto, Xiaochen Ji   +5 more
doaj   +1 more source

Efficacy of Monotherapy with Biologics and JAK Inhibitors for the Treatment of Rheumatoid Arthritis: A Systematic Review [PDF]

, 2018
Paul Emery, Janet Pope, Klaus Krüger, Ralph Lippe, Ryan DeMasi, Sadiq Lula, Blerina Kola   +6 more
openalex   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Jak inhibitors in the treatment of alopecia areata - a literature review

Journal of Education, Health and Sport
Introduction Alopecia areata (AA) is a chronic autoimmune disorder causing non-scarring hair loss, which can range from isolated patches to complete scalp (alopecia totalis, AT) or body hair loss (alopecia universalis, AU).
Paulina Krzeszowska, Aleksandra Kujawa, Karolina Krochmal, Wojciech Pisarek, Adrianna Samoraj, Jakub Zajączkowski, Kacper Stępniak, Jan Wilk, Karolina Marrodán-Wojtczak, Radosław Kuźma   +9 more
doaj   +1 more source

JAK-2 inhibitors and allogeneic transplant in myelofibrosis [PDF]

, 2015
7The activation of the JAK1/JAK2 pathway plays a crucial role in the pathogenesis of myelofibrosis. Treatment with the JAK2 inhibitor ruxolitinib demonstrated to reduce splenomegaly and symptoms in patients affected by myelofibrosis, leading to a ...
Cigana, C, De Marchi, R, Fanin, Renato, Lazzarotto, D, Patriarca, Francesca, Perali, G, Sperotto, A   +6 more
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Correction: JAK inhibitors and COVID-19

Journal for ImmunoTherapy of Cancer, 2023
doaj   +1 more source