Results 121 to 130 of about 126,141 (353)

JAK inhibitors: special issue foreword [PDF]

Expert Review of Clinical Immunology, 2022
James Galloway, Fabiola Atzeni
openaire   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

The Association Between Deep Vein Thrombosis, Pulmonary Embolism, and Janus Kinase Inhibitors: Reporting Status and Signal Detection in the Japanese Adverse Drug Event Report Database

Drugs - Real World Outcomes
Background Although Janus kinase (JAK) inhibitors have expanding indications, deep vein thrombosis (DVT) and pulmonary embolism (PE) are serious adverse events associated with their use. Moreover, their analysis using the Japanese database of spontaneous
Tae Maeshima, Sayaka Aisu, Naoki Ohkura, Machiko Watanabe, Fumio Itagaki   +4 more
doaj   +1 more source

JAK Inhibition Differentially Affects NK Cell and ILC1 Homeostasis

Frontiers in Immunology, 2019
Janus kinase (JAK) inhibitors are widely used in the treatment of multiple autoimmune and inflammatory diseases. Immunologic and transcriptomic profiling have revealed major alterations on natural killer (NK) cell homeostasis associated with JAK ...
Laura Vian, Mimi T. Le, Nathalia Gazaniga, Jacqueline Kieltyka, Christine Liu, Giuseppe Pietropaolo, Stefania Dell'Orso, Stephen R. Brooks, Yasuko Furumoto, Craig J. Thomas, Craig J. Thomas, John J. O'Shea, Giuseppe Sciumè, Massimo Gadina   +13 more
doaj   +1 more source

Real-world comparative effectiveness of bDMARDs and JAK inhibitors in elderly patients with rheumatoid arthritis

, 2022
Jumpei Temmoku, Kiyoshi Migita, Shuhei Yoshida, Haruki Matsumoto, Yuya Fujita, Naoki Matsuoka, Makiko Yashiro‐Furuya, Tomoyuki Asano, Shuzo Sato, Eiji Suzuki, Hiroshi Watanabe, Masayuki Miyata   +11 more
openalex   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Oncogenic JAK1 and JAK2-activating mutations resistant to ATP-competitive inhibitors

Haematologica, 2011
Background Activating mutations in JAK1 and JAK2 have been described in patients with various hematologic malignancies including acute lymphoblastic leukemia and myeloproliferative neoplasms, leading to clinical trials with JAK inhibitors.
Tekla Hornakova, Lorraine Springuel, Julien Devreux, Alexandra Dusa, Stefan N. Constantinescu, Laurent Knoops, Jean-Christophe Renauld   +6 more
doaj   +1 more source

Protein Tyrosine Phosphatase 1B (PTP1B) in the immune system [PDF]

, 2015
Journal not available online when checked 02/04/19.
Delibegovic, Mirela, Le Sommer, Samantha, Martin-Granados, Christina, Martina, Pesaresi   +3 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source