Results 101 to 110 of about 958,637 (251)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Selective JAK Inhibitor: Upadacitinib (JAK1-Selective)

The approval of upadacitinib, an oral selective inhibitor of Janus kinase 1 (JAK1), marks a significant advancement in the treatment of moderate-to-severe atopic dermatitis (AD).
Şeker, Ümmühan, Aydoğan, Kenan
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

JAK-STAT and bone metabolism

, 2013
Emerging evidences suggest Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway plays an important role in bone development and metabolism.
Li, Jiliang
core   +1 more source

The Association Between Deep Vein Thrombosis, Pulmonary Embolism, and Janus Kinase Inhibitors: Reporting Status and Signal Detection in the Japanese Adverse Drug Event Report Database

Drugs - Real World Outcomes
Background Although Janus kinase (JAK) inhibitors have expanding indications, deep vein thrombosis (DVT) and pulmonary embolism (PE) are serious adverse events associated with their use. Moreover, their analysis using the Japanese database of spontaneous
Tae Maeshima, Sayaka Aisu, Naoki Ohkura, Machiko Watanabe, Fumio Itagaki   +4 more
doaj   +1 more source

Janus kinase inhibitors as an evolving treatment for lymphomas and immune-mediated complications

Haematologica
The Janus kinase (JAK) and Signal Transducer and Activator of Transcription (STAT) signaling pathway orchestrates the cellular response to multiple cytokine families, including interleukins, hematopoietic growth factors, and interferons.
Caitlin Unkenholz, Sofía Huerga, Alison Moskowitz, Santosha Vardhana   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

JAK1-selective inhibitors versus pan-JAK inhibitors: comparative real-world study of drug retention in chronic inflammatory arthritis

Therapeutic Advances in Musculoskeletal Disease
Background: Janus kinase inhibitors (JAKi) are effective treatments for chronic inflammatory arthritis (CIA). Tofacitinib and baricitinib are pan-JAK inhibitors, while upadacitinib and filgotinib are JAK1-selective inhibitors. Objective: This study aimed
Leticia Leon, Pedro Pablo Bermejo, Leonor Laredo, Jose Alberto Peña Pedrosa, Maria Teresa Benítez Gimenez, Dalifer Freites, Clara de Miguel, Lydia Abasolo   +7 more
doaj   +1 more source