Results 111 to 120 of about 126,141 (353)
MedicinaBackground and Objectives: Atopic dermatitis is a chronic inflammatory skin disorder with a significant burden on patients’ quality of life. This systematic review aims to evaluate the restoration of skin barrier abnormalities with interleukin-4 ...
Isidora Chatzigeorgiou +4 more
doaj +1 more source
Mediators of Inflammation, 2006 In inflammation, inducible nitric oxide synthase (iNOS) produces nitric oxide (NO), which modulates inflammatory processes. We investigated the effects of Janus kinase (JAK) inhibitors, AG-490 and WHI-P154, on iNOS expression and NO production in J774 ...
Outi Sareila +5 more
doaj +1 more source
Genetic Relationships and Therapeutic Options for Relapsed Acute Lymphoblastic Leukemia [PDF]
, 2020 Acute lymphoblastic leukemia (ALL) is the most common form of cancer among children and can be lethal to the adult population. Though 80% of patients with ALL reach complete remission after treatment, about 20% of those diagnosed fail to remain cancer ...
Shertzer, Hailie
core +1 more source
A key role for leukemia inhibitory factor in C26 cancer cachexia [PDF]
, 2015 Cachexia is an exacerbating event in many types of cancer that is strongly associated with a poor prognosis. We have identified cytokine, signaling, and transcription factors that are required for cachexia in the mouse C26 colon carcinoma model of cancer.
Jackman, Robert W. +2 more
core +1 more source
Buying into JAK Inhibitors [PDF]
Cancer Discovery, 2013 Abstract Gilead Sciences of Foster City, CA, has offered $510 million for YM BioSciences of Mississauga, Ontario, Canada, whose primary product, CYT387, is an early-stage JAK1 and JAK 2 inhibitor.
openaire +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Tofacitinib in the management of active psoriatic arthritis: patient selection and perspectives. [PDF]
, 2019 Tofacitinib is an oral Janus kinase inhibitor approved for the treatment of psoriatic arthritis (PsA). It provides an alternative option for patients who have had an inadequate response and tolerance to other disease modifying antirheumatic drugs (DMARDs)
Beck, Kristen M +4 more
core
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
JAK inhibitors for the treatment of VEXAS syndrome [PDF]
, 2023 Sara Bindoli +4 more
openalex +1 more source